Direct reductive amination of aldehydes and selective reduction of α,β-unsaturated carbonyl compounds by NaBH4 in the presence of guanidine hydrochloride in water

Reductive amination of aldehydes and ketones by NaBH4using carbon-based solid acid (CBSA) as catalyst

“…For these conversions, hydrogen can be produced as reducing agent in the presence of metal catalysts (4Á8), ZnÁAcOH (9), Et 3 SiHÁCF 3 CO 2 H (10), Bu 3 SnHÁ DMF (11), NaBH 4 along with catalysts such as various acids (12), boric acid/p-toulenesulfonic acid/ benzoic acid (13), boric acid (14), acetic acid (15), trifluoroacetic acid (16), silica-phosphoric acid (17), iodine (18), indium chloride (19), guanidine-hydrochloride (20), 12-tungstophosphoric acid (21), ionic liquids (22), titanium (IV) isopropoxide (23), and polyaniline salt (PANI) (24). In addition, there are some reports on development of electrochemical reductive amination reactions (25Á27).…”

New potential of the reductive alkylation of amines

“…50 A convenient preparative procedure has been developed for the reductive alkylation with NaBH 4 in the presence of tungstophosphoric acid H 3 PW 12 O 40 Ð a strong heteropoly acid more efficient in acid catalysis than other inorganic and organic protonic acids. This acid does not induce corrosion and is readily separated from the reaction products.…”

NaBH4/C: A Convenient System for Reductive Amination of Aldehydes

“…Because, other approaches such as: the reduction of nitro, cyano, azide, carboxamide compounds or the alkylation of amines are often problemssuch as: harsh reaction conditions, overalkylation, low chemical selectivity and generally poor yields. The reductive aminationreactionhas been carried out by sodium borohydridewith different reducing system [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15] .But, in continuing our efforts for the development of new reducing systems [16][17][18][19][20][21][22][23][24][25][26][27][28] ,in this context, we have reported the reductive amination reaction of aldehydes with anilines by NaBH 4 /C system in THF.…”