Direct quantitation and characterization of fatty acids in salmon tissue by condensed phase membrane introduction mass spectrometry (CP-MIMS) using a modified donor phase

Abstract

Direct quantitation and characterization of fatty acids in salmon tissue by condensed phase membrane introduction mass spectrometry (CP-MIMS) using a modified donor phase.

Direct mass spectrometric analysis of naphthenic acids and polycyclic aromatic hydrocarbons in waters impacted by diluted bitumen and conventional crude oil

“…The acceptor phase (typically methanol), containing the membrane-permeable fraction of the sample, is then infused into an appropriate ionization source, often electrospray or liquid electron ionization (Termopoli et al, 2019a;Vandergrift et al, 2020), to provide real-time results, which can be employed to provide both qualitative and quantitative data. This method has been applied to a wide range of analytes and sample matrices, including pharmaceuticals in wastewater (Duncan et al, 2016b), fatty acids in salmon tissue (Borden et al, 2019), NAs in water (Duncan et al, 2016a) and constructed wetlands (Duncan et al, 2020), PAHs in water and soil samples (Termopoli et al, 2016;Vandergrift et al, 2019), and the determination of acid dissociation constants of trace organic contaminants in aqueous solutions (Feehan et al, 2019). Herein, we determine aqueous-phase concentrations of NA and PAH contaminants in constructed water samples containing DB and CC oil over a range of salinity and pH.…”

Mass Spectrometry Based Approach for Organic Synthesis Monitoring

“…To date, the majority of CP-MIMS type measurements have been made in aqueous samples. ,,, It is known that solvent-membrane solubility can significantly influence membrane permeability. − We have begun to exploit acceptor phase cosolvents with CP-MIMS by forming in situ polymer inclusion membranes, which improve both the sensitivity and measurement duty cycle. , In addition, recent developments utilizing modified donor phases (e.g., mixed organic sample solvents) with CP-MIMS have shown promise for making direct measurements of fatty acids . However, because synthetic reactions are most often conducted in nonaqueous solvents, the analytical performance of PDMS membranes in a variety of nonaqueous sample solvents was investigated.…”

“…30,36 In addition, recent developments utilizing modified donor phases (e.g., mixed organic sample solvents) with CP-MIMS have shown promise for making direct measurements of fatty acids. 38 However, because synthetic reactions are most often conducted in nonaqueous solvents, the analytical performance of PDMS membranes in a variety of nonaqueous sample solvents was investigated.…”

A Direct Mass Spectrometry Method for the Rapid Analysis of Ubiquitous Tire-Derived Toxin N-(1,3-Dimethylbutyl)-N′-phenyl-p-phenylenediamine Quinone (6-PPDQ)

“…CP-MIMS typically employs a semipermeable polydimethylsiloxane (PDMS) capillary hollow fiber membrane (CHFM) to separate hydrophobic analytes from interfering matrix components (e.g., salts and particulate matter) directly in liquid/slurry samples. , An organic acceptor continuously passed through the CHFM transports permeating analytes to the MS ion source. , This approach has been paired with both electrospray ionization (ESI) − and liquid electron ionization (LEI), − enabling direct measurements of a wide array of analytes in diverse, complicated matrices, including PAHs in natural waters and sediments, , naphthenic acids in constructed wetlands and oil-affected waters, pharmaceuticals in wastewater, and fatty acids in fish . The perm-selectivity of analytes with acid/base properties is pH-dependent and has been used to derive the p K a of trace organics in water .…”