We study the direct product of automorphism groups of digraphs, where automorphism groups are considered as permutation groups acting on the sets of vertices. By a direct product of permutation groups (A, V) × (B, W) we mean the group (A × B, V × W) acting on the Cartesian product of the respective sets of vertices. We show that, except for the infinite family of permutation groups S n × S n , n ≥ 2, and four other permutation groups, namely