Direct Oral Anticoagulant Use Early After Cardiac Surgery: A Retrospective Cohort Study

Wu, Jung-Jin; Jiang, Jessie; Ye, Jian; Turgeon, Ricky D.; Wang, Erica H.Z.

doi:10.1016/j.cjco.2023.09.017

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Step 1: Define the Clinical (Research) Question1

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2024

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“…• First, we conducted a retrospective observational study at our Canadian quaternary referral center for cardiac surgery to determine the rate and characterize the use of NOACs early after cardiac surgery and its determinants. 35 This informed the population of interest and features of both a NOAC intervention arm and warfarin comparator arm for a pilot RCT, as described below.…”

Section: Step 1: Define the Clinical (Research) Questionmentioning

confidence: 99%

Research and scholarly methods: Appraising the available literature to inform a research project

MacDonald,

Wang,

Turgeon

2024

J Am Coll Clin Pharm

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A literature review with an evaluation of existing evidence is often the first step in designing a research project. This article provides a systematic framework and guide for clinicians, researchers, and clinician‐scientists to appraise the available literature to inform a clinical research project. The three‐step approach outlined in this article starts with defining your research question using the Population Intervention Comparator Outcome‐Design framework, followed by evaluation of the existing evidence and identification of gaps that could be addressed by a research project, and ends with guidance to refine the research question and start preparing a protocol.

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Section: Step 1: Define the Clinical (Research) Questionmentioning

confidence: 99%