SummaryThe aim of this work has been assessment of regional atmospheric influence on satellite derivation of the Adriatic Sea surface temperature (SST). To that end the ECMWF ERA-40 reanalysis dataset has been employed to provide the temperature and humidity profiles and surface data, while the RTTOV 8.7 radiative transfer model was used to calculate the top of atmosphere brightness temperatures for the AVHRR channels. Ten ERA-40 grid points over the Adriatic Sea were used in the analysis, providing 29590, 00 UTC and 12 UTC, clear-sky profiles.Climatological analysis of the ERA-40 profiles demonstrated a distinct seasonal variability over the Adriatic. Seasonality noted in the temperature and specific humidity profiles also evinced in the atmospheric transmittance, thermal channels temperature deficit, and derived γ and ρ parameters. A multivariate analysis was applied to relate the simulated top of the atmosphere (TOA) brightness temperatures (BT) to the Adriatic SSTs, in order to generate exploratory sets of SST retrieval coefficients. All 10 derived coefficient sets exhibited smaller noise amplification factor than the global counterpart. A test comparison of satellite-derived SST with an eleven-month in situ SST series showed than locally derived coefficients provide smaller scatter (improved precision), and bias that requires empirical adjustment before operational use. Almost identical SST residual and metrics was obtained with seasonally adjusted "classical" split-window coefficients and with coefficients explicitly accommodating water vapour dependence. The comparison to data has reinforced the notion that the over-the-Adraitic atmosphere may exhibit variability which globally adjusted correction can not fully accommodate.