Chiral d-wave superfluid is a preliminary example of topological matters that intrinsically encodes interaction effects. It exhibits fascinating properties including a finite Chern number in the bulk and topologically protected edge states, which have been invoking physicists for decades. However, unlike s-wave superfluids prevalent in nature, its existence requires a strong interaction in the d-wave channel, a criterion that is difficult to access in ordinary systems. So far, such an unconventional superfluid has not been discovered in experiments. Here, we present a new principle for creating a two-dimensional chiral d-wave superfluid using periodically driven lattices. Due to an imprinted two-dimensional pseudospin-orbit coupling, where the sublattice index serves as the pseudospin, s-wave interaction between two hyperfine spin states naturally creates a chiral d-wave superfluid. This scheme also allows physicists to study the phase transition between the topologically distinct s-and d-wave superfluids by controlling the driving field or the particle density.Superfluidity takes center stage in modern condensed matter physics [1,2]. Whereas a large number of elements on the periodic table become superfluids or superconductors at low temperatures, most of them are conventional s-wave ones. Though superfluidity could also occur in high-partial-wave channels, such as p-wave superfluids in Helium and d-wave superconductors in cuprates [3,4], it is very rare that a high-partial-wave superfluidity is accompanied by the time-reversal symmetry breaking. Such chiral superfluids, for instance, the p x + ip y and d x 2 −y 2 + id xy superfluids [5][6][7][8][9][10], give rise to exotic phenomena in an interacting many-body system. It has been realized that one need go beyond the conventional symmetry breaking paradigm to describe these chiral superfluids, since they are distinguished from their counterparts that respect the time-reversal symmetry, such as p x and d x 2 −y 2 , by a finite Chern number, a topological property in the bulk, and chiral edge states protected by topology in a finite system. There have been experimental evidences for the p x + ip y superconductor, which exhibits a Chern number C = 1, to exist in Sr 2 RuO 4 [11]. For the chiral d x 2 −y 2 + id xy superfluid with a Chern number C = 2, there has been no experimental observation yet.To realize a chiral d x 2 −y 2 + id xy superfluid, theoretical studies have proposed using doped graphene for enhancing the d-wave interaction [12], or magnetic impurities for mixing d xy with d x 2 −y 2 in cuprates [9,13]. These proposals requiring sophisticated doping of solid materials have not been realized in experiments so far. In ultracold atoms, though the interaction can be tuned by Feshbach resonance, the strong atom loss near high-partial-wave resonance makes it challenging to explore chiral superfluids with a large d-wave scattering length [14,15]. Here, we propose a new scheme that simply requires s-wave interaction. The idea is to engineer a special band stru...