Direct monitoring of laser absorption of MALDI matrices by fast piezoelectric transducer

Taranenko, N. I.; Golovlev, V. V.; Puretzky, Alexander A.; Allman, S. L.; Chen, C.H.

doi:10.1016/0009-2614(95)00036-4

Cited by 2 publications

(2 citation statements)

References 11 publications

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“…41 There have been few studies of acoustic transients generated in conventional front-surface irradiated MALDI so that experimental evidence to support stress wave effects in desorption is lacking. One exception is the work of Taranenko et al, 128 who applied fast piezoelectric transducers to monitor the absorption of 266 and 355 nm laser radiation in MALDI matrices through the thermoelastic stress waves generated by rapid heating. A nonlinear scaling of acoustic signal amplitude with fluence was observed for some wavelength-sample combinations and attributed to multistep absorption rather than ablation recoil.…”

Section: Photomechanical Effects In Maldimentioning

confidence: 99%

Photomechanical Processes and Effects in Ablation

2003

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Section: Photomechanical Effects In Maldimentioning

confidence: 99%

Photomechanical Processes and Effects in Ablation

2003

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“…The quality of MALDI-MS spectra is strongly dependent on numerous factors, such as the photophysical and photochemical properties of the matrix and analytes [3][4][5][6][7][8][9][10][11][12] and laser irradiation conditions [13][14][15][16][17][18]. Moreover, selecting a suitable matrix for the target analyte is crucial.…”

Section: Introductionmentioning

confidence: 99%

Vacuum Ultraviolet Single-Photon Postionization of Amino Acids

Hsu

2018

Applied Sciences

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In this study, ultraviolet (UV) laser desorption and vacuum UV single-photon (VUV SP) postionization were performed to ionize and successfully analyze 20 common amino acids. The analytical merit and efficiency of the ionization was compared with those of conventional UV matrix-assisted laser desorption ionization (UV-MALDI). A VUV light source (118 nm) was generated from the ninth harmonic of a Q-switched Nd:YAG laser, and the photon number was determined to be larger than 10 12 for each laser pulse in the ionization region. In general, the detection sensitivity of VUV-SP-postionization was 10-100 times higher than that of conventional UV-MALDI. In particular, the ion signal from VUV-SP-postionization was considerably larger than that from UV-MALDI for analytes with low proton affinity such as glycine. However, some fragmentation of intact ions was observed in VUV-SP-postionization. Quantitative analysis performed using a glycine/histidine mixture and tryptophan/phenylalanine mixture revealed that the dynamic range of VUV-SP-postionization was one order of magnitude larger than that of UV-MALDI, indicating that VUV-SP-postionization is suitable for the quantitative analysis of amino acids.

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Direct monitoring of laser absorption of MALDI matrices by fast piezoelectric transducer

Cited by 2 publications

References 11 publications

Photomechanical Processes and Effects in Ablation

Photomechanical Processes and Effects in Ablation

Vacuum Ultraviolet Single-Photon Postionization of Amino Acids

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