The neutrinoless double-beta (0ν2β) decay is currently the only feasible process in particle and nuclear physics to probe whether massive neutrinos are the Majorana fermions. If they are of a Majorana nature and have a normal mass ordering, the effective neutrino mass term m ee of a 0ν2β decay may suffer significant cancellations among its three components and thus sink into a decline, resulting in a "well" in the three-dimensional graph of | m ee | against the smallest neutrino mass m 1 and the relevant Majorana phase ρ. We present a new and complete analytical understanding of the fine issues inside such a well, and identify a novel threshold of | m ee | in terms of the neutrino masses and flavor mixing angles: | m ee | * = m 3 sin 2 θ 13 in connection with tan θ 12 = m 1 /m 2 and ρ = π . This threshold point, which links the local minimum and maximum of | m ee |, can be used to signify observability or sensitivity of the future 0ν2β-decay experiments. Given current neutrino oscillation data, the possibility of | m ee | < | m ee | * is found to be very small.Since Majorana first formulated a fermionic particle that should be its own antiparticle in 1937 [1], a huge amount of attention has been paid to the Majorana fermions in particle and nuclear physics and the Majorana zero modes in solid-state physics [2]. In particular after the experimental discoveries of solar, atmospheric, reactor and accelerator neutrino oscillations [3], whether massive neutrinos are Majorana fermions becomes an especially burning question among a number of fundamentally important questions in neutrino physics and cosmology. If this is the case, then the neutrinoless double-beta (0ν2β) decays of some even-even nuclei are expected to take place [4]. Namely, N (A, Z ) → N (A, Z + 2) + 2e − , where the lepton number is violated by two units. Given the fact that the neutrino masses are so small that all the lepton-number-violating processes must be desa e-mail: zhaozhenhua@ihep.ac.cn perately suppressed, currently the unique and only feasible way to demonstrate the Majorana nature of massive neutrinos is to observe the 0ν2β decays. In this respect a number of ambitious experiments are either under way or in preparation [5][6][7].In the standard scheme of three neutrino flavors the rate of a 0ν2β decay is proportional to the squared modulus of the effective Majorana neutrino mass term [8][9][10] where m i denotes the ith neutrino mass (for i = 1, 2, 3), U ei is the corresponding element of the 3 × 3 neutrino mixing matrix U [14,15], and ρ and σ stand for the Majorana phases. One often chooses to parametrize |U ei | as follows [3]: |U e1 | = cos θ 12 cos θ 13 , |U e2 | = sin θ 12 cos θ 13 , and |U e3 | = sin θ 13 . The three mixing angles θ 12 , θ 13 and θ 23 have been determined to a good degree of accuracy from current neutrino oscillation data, so have been the value of m 2 21 ≡ m 2 2 − m 2 1 and the modulus of m 2 31 ≡ m 2 3 − m 2 1 [3]. But the sign of m 2 31 and the two phase parameters in Eq. (1) remain unknown, nor does the ...