Direct mass analysis of neutral molecules by superconductivity

Ohkubo, M.; Shiki, Shigetomo; Ukibe, Masahiro; Tomita, S.; Hayakawa, Shigeo

doi:10.1016/j.ijms.2010.09.027

Cited by 18 publications

(22 citation statements)

References 42 publications

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“…When neutral fragments are produce in MS instruments, they disappear. The kinetic energy measurement can also solve the neutral loss [12], since the kinetic energy of a precursor ion is divided into fragments according to the fragment mass values. Even if all fragments are neutral, it is possible to analyze gas phase reaction branches using the STJ detectors.…”

Section: Resultsmentioning

confidence: 99%

Superconducting Molecule Detectors Overcoming Fundamental Limits of Conventional Mass Spectrometry

et al. 2012

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Mass spectrometry (MS) is widely used in analytical chemistry for such fields as environmental science, life science, and space science. However, MS has two fundamental limits: the mass peak overlap of ions with the same mass/charge-number (m/z) ratio but different charge states (m/z overlap), and no ability to distinguish different neutral molecules (neutral loss). We show that these limits can be overcome by using superconducting detectors. Superconducting tunnel junctions (STJ) molecule detectors and superconducting nanostripline detectors (SSLDs) are suitable for MS because of the choice of fast ns response.

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Section: Resultsmentioning

confidence: 99%

Superconducting Molecule Detectors Overcoming Fundamental Limits of Conventional Mass Spectrometry

et al. 2012

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“…This problem of surface contamination can be common also to the case of TOF-MS, although is less relevant since no effects have been observed, probably because of the higher energy of the impacts and phonon propagation through the surface contaminant that is solid at low temperatures. In fact, it was reported that the phonons produced by the impact of 3 keVacetyl-ions (CH 3 CO + ) on the 700 nm-thick SiO 2 insulation layer that covered the top Nb electrode of an STJ broke Cooper pairs in the Nb electrode [26]. Moreover, the SSPD used in Ref.…”

Section: Particle Detection With Superconductorsmentioning

confidence: 99%

“…Detection of the doubly-charged ions is important for investigating atmosphere escape from planets. Thanks to the property of charge discrimination the interest for STJs is still alive [26], [40]. However, in an STJ the kinetic energy measurement is followed by the dead time of 1-20 µs, which is unreasonably slow for modern high-resolution time-of-flight analyzers.…”

Section: Charge Discrimination and True Mass Spectrometrymentioning

confidence: 99%

Superconducting nano-strip particle detectors

Cristiano

Ejrnæs

Casaburi

et al. 2015

Supercond. Sci. Technol.

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We review progress in the development and applications of superconducting nano-strip particle detectors. Particle detectors based on superconducting nano-strips stem from the parent devices developed for single-photon detection (SSPD) and share with them ultrafast response time (sub-nanosecond) and operation at a relatively high temperature (2 -5 K) with respect to other cryogenic detectors. SSPDs have been used in the detection of electrons, neutral and charged ions, and biological macromolecules. Nevertheless, the development of superconducting nano-strip particle detectors has been mainly driven by the use in time-of-flight mass spectrometers (TOF-MS) where the goal of 100% efficiency at large mass values can be obtained. A special emphasis will be given to this case, reporting the great progress achieved which permits to overcome the limitations of existing mass spectrometers represented by low detection efficiency at large masses and charge/mass ambiguity and could represent a breakthrough in the field. In this review article we will introduce the device concept and detection principle, stressing the peculiarities of the nano-strip particle detector as well as its similarities with the photon detector. The development of the parallel strip configuration is introduced and extensively discussed, since it has contributed to significant progress in TOF-MS applications.

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“…82 We are aware of only one study on acetone radical fragmentation capable of also collecting neutral fragments. In specific, Ohkubo et al 44 used a cryogenic STJ detector in a novel mass spectrometry approach for their investigations of 3 keV acetone radicals colliding with Xe atoms. They explained their data by two additional ETD channels producing solely neutral fragments…”

Section: E Acetone Radical Fragmentationmentioning

confidence: 99%

Cryogenic micro-calorimeters for mass spectrometric identification of neutral molecules and molecular fragments

Novotný

Allgeier

Enss

et al. 2015

Journal of Applied Physics

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We have systematically investigated the energy resolution of a magnetic micro-calorimeter (MMC) for atomic and molecular projectiles at impact energies ranging from E ≈ 13 to 150 keV. For atoms we obtained absolute energy resolutions down to ∆E ≈ 120 eV and relative energy resolutions down to ∆E/E ≈ 10 −3 . We also studied in detail the MMC energy-response function to molecular projectiles of up to mass 56 u. We have demonstrated the capability of identifying neutral fragmentation products of these molecules by calorimetric mass spectrometry. We have modeled the MMC energy-response function for molecular projectiles and conclude that backscattering is the dominant source of the energy spread at the impact energies investigated. We have successfully demonstrated the use of a detector absorber coating to suppress such spreads. We briefly outline the use of MMC detectors in experiments on gas-phase collision reactions with neutral products. Our findings are of general interest for mass spectrometric techniques, particularly for those desiring to make neutral-particle mass measurements.

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Direct mass analysis of neutral molecules by superconductivity

Cited by 18 publications

References 42 publications

Superconducting Molecule Detectors Overcoming Fundamental Limits of Conventional Mass Spectrometry

Superconducting Molecule Detectors Overcoming Fundamental Limits of Conventional Mass Spectrometry

Superconducting nano-strip particle detectors

Cryogenic micro-calorimeters for mass spectrometric identification of neutral molecules and molecular fragments

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