Direct intramolecular carbon(sp²)–nitrogen(sp²) reductive elimination from gold(iii)

Abstract

The reactivity of bidentate AuIII–Cl species, [(C^N)AuCl2], with a bisphosphine or carbon donor ligands results in reductive elimination.

Recent Advances in Gold(III) Chemistry: Structure, Bonding, Reactivity, and Role in Homogeneous Catalysis

“…(Scheme 56). 341 The same result was obtained by reacting 165 with chelating diphosphines. The reaction was proposed to be initiated by the coordination of the carbene generated in situ from the imidazolium salt.…”

Gold(I/III)-Phosphine Complexes as Potent Antiproliferative Agents

“…This is as a result of reductive elimination promoted by the nucleophilic phosphine. It is a subject of intense investigation within our laboratory 68 . Complexes 4 and 5 bearing DPPE ligands were synthesized to investigate the effect of perchlorate counter anions on cellular activity.…”

Anticancer gold(iii)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition

“…Signicant progress in understanding the structure and reactivity of selected gold(III) complexes has provided new impetus for the use of gold compounds. [30][31][32][33][34][35][36] Previous and ongoing contributions to surmount challenges associated with physiologically relevant gold compounds as anticancer libraries through innovative chemistries [37][38][39] continue to expand via the development of new scaffolds including gold-porphyrin, 9,[40][41][42][43][44] gold-phosphine, [45][46][47][48][49][50][51] and cyclometalated gold variations. [52][53][54][55][56][57] Additionally, our synthetic efforts have led to the generation of [C^N]cyclometalated gold(III) compounds, which present strong sigma-donation of electrons to stabilize the gold center.…”