Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity

Kim, Kwang-Woon; Kim, Sun‐Hee; Shin, J Y; Kim, Gui-Sook; Son, Young‐Ok; Park, Soon-Won; Kwon, Byung-Hyun; Kim, Dong-Won; Lee, Chang-Hun; Sol, Mee-Young; Jeong, Min-Ho; Chung, Byung-Seon; Kang, Chi‐Dug

doi:10.1002/ijc.20036

Cited by 74 publications

(55 citation statements)

References 28 publications

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“…These findings and those from a recent study, which has shown a synergistic antitumor effect in mice treated with local irradiation and intratumoral injections of DCs (45), indicate that DCs may be limiting and that increasing their numbers and function may increase tumor destruction. Thus, it is possible that tumors grow out despite increased numbers of T cells in the draining lymph node because of the inadequate Ag presentation in lymph nodes.…”

Section: Discussionsupporting

confidence: 66%

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

Lugade

Moran

Gerber

et al. 2005

The Journal of Immunology

844

660

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Immunotherapy of cancer is attractive because of its potential for specificity and limited side effects. The efficacy of this approach may be improved by providing adjuvant signals and an inflammatory environment for immune cell activation. We evaluated antitumor immune responses in mice after treatment of OVA-expressing B16-F0 tumors with single (15 Gy) or fractionated (5 × 3 Gy) doses of localized ionizing radiation. Irradiated mice had cells with greater capability to present tumor Ags and specific T cells that secreted IFN-γ upon peptide stimulation within tumor-draining lymph nodes than nonirradiated mice. Immune activation in tumor-draining lymph nodes correlated with an increase in the number of CD45+ cells infiltrating single dose irradiated tumors compared with nonirradiated mice. Similarly, irradiated mice had increased numbers of tumor-infiltrating lymphocytes that secreted IFN-γ and lysed tumor cell targets. Peptide-specific IFN-γ responses were directed against both the class I and class II MHC-restricted OVA peptides OVA257–264 and OVA323–339, respectively, as well as the endogenous class I MHC-restricted B16 tumor peptide tyrosinase-related protein 2180–188. Adoptive transfer studies indicated that the increased numbers of tumor Ag-specific immune cells within irradiated tumors were most likely due to enhanced trafficking of these cells to the tumor site. Together these results suggest that localized radiation can increase both the generation of antitumor immune effector cells and their trafficking to the tumor site.

show abstract

Section: Discussionsupporting

confidence: 66%

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

Lugade

Moran

Gerber

et al. 2005

The Journal of Immunology

844

660

View full text Add to dashboard Cite

show abstract

“…It has been widely hypothesized that tumor irradiation activates effectors of innate immunity through the induction of tumor cell apoptosis and the release of endogenous TLR agonists. The observation that such ubiquitous factors as heat-shock proteins and uric acid can act through TLRs and induce DC maturation (Gallucci et al, 1999) supports this mechanism as does the demonstration that immature DCs, when administered into irradiated tumors, induce antitumor immunity (Kim et al, 2004). Most recently, the high-mobility-group box 1 alarmin protein, released by dying tumor cells, was shown to act on TLR4 expressed by DCs.…”

Section: Radiation-induced Tlr Signalingmentioning

confidence: 86%

Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer

Roses

Koski

et al. 2008

Oncogene

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“…It has been widely hypothesized that tumor irradiation activates effectors of innate immunity through the induction of tumor cell apoptosis and the release of endogenous TLR agonists. The observation that such ubiquitous factors heat-shock proteins and uric acid can act through TLRs and induce DC maturation (Gallucci et al, 1999) supports this mechanism as does the demonstration that immature DCs, when administered into irradiated tumors, induce antitumor immunity (Kim et al, 2004).Most recently, the high-mobility-group box 1 alarmin protein, released by dying tumor cells, was shown to act on TLR4 expressed by DCs. Moreover, binding of TLR4 was demonstrated to increase the efficiency of tumor antigen processing and presentation (Apetoh et al, 2007).…”

Section: Radiation-induced Tlr Signalingmentioning

confidence: 87%

Radiotherapy and Immunity – A Mini Review

Villar¹

2012

Immunosuppression - Role in Health and Diseases

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Direct injection of immature dendritic cells into irradiated tumor induces efficient antitumor immunity

Cited by 74 publications

References 28 publications

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

Local Radiation Therapy of B16 Melanoma Tumors Increases the Generation of Tumor Antigen-Specific Effector Cells That Traffic to the Tumor

Radiation therapy and Toll-like receptor signaling: implications for the treatment of cancer

Radiotherapy and Immunity – A Mini Review

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