Abstract:and Gem/Kir (RGK) sub-family of small GTP-binding protein include e the most potent endogenous inhibitor of High-Voltage Activated (HVA) calcium channels. RGK proteins use several mechanisms to inhibit calcium current (I CA): i) they promote dynamin-dependent endocytocys; ii) the lower the Po of the channel: ii) and they voltage sensor or reduction of charge. All RGK proteins associate directly with Ca 2þ channel b subunits (Cavb), and the binding between CaVa1 / Cavb has been shown to be essential for their i… Show more
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