Direct inguinal herniation in men: A disease of collagen

Wagh, Premanand V.; Leverich, Ann P.; Sun, Chao; White, Harold J.; Read, Raymond C.

doi:10.1016/0022-4804(74)90155-3

Cited by 139 publications

(75 citation statements)

References 10 publications

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“…An approximate 73% amount of collagen was found in the fascia transversalis, very similar to the literature that states values of approximately 75% as the average (26) .…”

Section: Discussionsupporting

confidence: 88%

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Meyer¹,

Berger²,

Monteiro³

et al. 2007

Arq. Gastroenterol.

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-Background -Inguinal hernia is the second most common surgical case in our field. The anatomical factors alone are not enough to explain the inguinal hernia. Studies show changes in the proportion and quantity of collagen fibers in the developing of inguinal hernia. The greater production of collagen type III compared to the type I could justify the thinning of the fascia transversalis and its weakness. Aim -To determine the quantitative and qualitative changes of collagen in the fascia transversalis in inguinal hernia patients and compare them to findings from corpses without inguinal hernia. Method -Prospective case-control study based on the biopsy of fascia transversalis of 27 patients and 24 corpses. The technique used was hematoxylin-eosin and picrosirius colorimetry. Results -The medium percent area of collagen (types I + III) and collagen type I, in both groups, show no statistic difference. The quantity of collagen type III was greater in the patients. Patients classified with Nyhus IIIa presented greater quantity of collagen type III. Conclusion -There is no significant difference in the quantity of collagen in the fascia transversalis of patients compared to the controls. An increase in the quantity of collagen type III was found in patients with inguinal hernia and a greater quantity in those patients classified with Nyhus IIIa. HEADINGS -Hernia, inguinal. Fascia. Collagen.

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“…An approximate 73% amount of collagen was found in the fascia transversalis, very similar to the literature that states values of approximately 75% as the average (26) .…”

Section: Discussionsupporting

confidence: 88%

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Meyer¹,

Berger²,

Monteiro³

et al. 2007

Arq. Gastroenterol.

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“…Lanes 2,5,8: patient rectus sheaths. Lanes 3,6,9: fascias from the nonherniated side. Lane 4: fascia from femoral hernia.…”

Section: Fig 1 Example Of Collagen Electrophoresis In Sds-polyacrylmentioning

confidence: 99%

“…In light of the works of Peacock and Madden [3] and that of Wagh et al [4][5][6][7], it appeared that hernia formation might be based on collagen metabolism anomalies. Hence, inguinal hernia could be considered a local manifestation of a more generalized collagen pathology.…”

Section: Introductionmentioning

confidence: 99%

Biochemical Study of Collagen in Adult Groin Hernias

Pans¹,

Albert²,

Lapière³

et al. 2001

Journal of Surgical Research

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Background. Previous works have suggested that a defect in collagen fiber structure may play a role in inguinal hernia formation. These studies focused mainly on the rectus sheath or the skin, while only few reports dealt with the transversalis fascia. According to these findings and to our previous biomechanical and histological studies suggesting that a connective tissue pathology could play a role in the genesis of groin hernias, we performed a biochemical investigation of the collagen in the transversalis fascia and rectus sheath.

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“…Subsequent biochemical research on cases of inguinal herniation revealed disordered connective tissue metabolism in the extracellular matrix (ECM), resulting in diminished and abnormal collagen [13][14][15][16]. Biopsies of skin and pericardium showed similar pathology, signifying systemic disease [17]. These findings were confirmed and extended to other abdominal defects by herniologists from around the world.…”

Section: Hernial Diseasementioning

confidence: 99%

Systemic hernial disease protects against cancer: an hypothesis

Read

2009

Hernia

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Research by herniologists from around the world has shown that abdominal defects, in the adult, are not caused by wear and tear but systemic hernial disease (herniosis), a disorder of connective tissue which affects the extracellular matrix (ECM). Wound healing may be affected, leading to recurrences after hernia repair or primary incisional herniation. Women with genitourinary prolapse show signs of herniosis in the pelvis. Diverticulosis coli, commonly seen in the elderly, like hernia, was once attributed to stress and strain from constipation. It is now suspected that herniosis weakens the colonic ECM, allowing the mucosa to form diverticula by herniating alongside the vasa recta. Remarkably, clinical studies of Saint's triad extending over the past 60 years have repeatedly demonstrated a highly significant relationship between colonic diverticula and abdominal herniae. Krones et al. (Int J Colorectal Dis 21:18-24, 2006) reported that diverticula and cancer are rarely coincident in the colon, despite aging. Their data indicate that the two pathologies arise in different ECMs.

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Direct inguinal herniation in men: A disease of collagen

Cited by 139 publications

References 10 publications

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Quantitative and qualitative analysis of collagen types in the fascia transversalis of inguinal hernia patients

Biochemical Study of Collagen in Adult Groin Hernias

Systemic hernial disease protects against cancer: an hypothesis

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