Direct Influence of Temperature on the Semicircular Canal Receptor

Suzuki, Mamoru; Kadir, Abdul; Hayashi, Naoki; Takamoto, Muneo

doi:10.3233/ves-1998-8205

Cited by 7 publications

(2 citation statements)

References 11 publications

(6 reference statements)

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“…One potential limitation of this study is not having a direct measure of temperature in the otolith organs and semicircular canals. Previous studies have identified direct effects of temperature on endolymph and vestibular hair cell function (23,35). The whole body heating protocol significantly increased internal and mean skin temperature, but these increases may have not caused changes in endolymph or vestibular hair cell function.…”

Section: Discussionmentioning

confidence: 95%

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Vestibular activation does not influence skin sympathetic nerve responses during whole body heating

Wilson

Kuipers²,

McHugh³

et al. 2004

Journal of Applied Physiology

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The cutaneous vasculature and eccrine sweat glands are modified by both thermal and nonthermal factors. To determine the effect of thermal stress on the vestibulosympathetic reflex, skin sympathetic nerve activity (SSNA) and cutaneous end-organ responses were measured in 10 subjects during static head-down rotation (HDR) and dynamic yaw and pitch (30 cycles/min) to activate the otolith organs and semicircular canals. SSNA (microneurography of peroneal nerve), cutaneous vascular conductance (CVC; laser-Doppler flux/mean arterial pressure), sweat rate (capacitance hygrometry), and body temperature were collected during normothermia and after whole body heating. Body temperature was controlled by perfusing neutral (34-35 degrees C) or warm (44-46 degrees C) water through a tube-lined suit. During normothermia, HDR did not alter SSNA (-0.4 +/- 4.4% change), CVC (4.2 +/- 6.9% change), or sweat rate (-2.7 +/- 1.2% change) within the innervated area of skin. Dynamic yaw and pitch also did not elicit significant changes in SSNA, CVC, or sweat rate during normothermia. Whole body heating significantly increased internal temperature (0.8 +/- 0.1 degrees C), mean skin temperature (4.1 +/- 0.2 degrees C), CVC (322 +/- 109% control), and sweat rate (0.35 +/- 0.08 mg.cm(-2).min(-1)). After whole body heating, HDR did not significantly alter SSNA (3.2 +/- 7.6% change), CVC (-7.3 +/- 3.9% change), or sweat rate (-3.3 +/- 1.9% change). Dynamic yaw and pitch also did not produce significant changes in SSNA, CVC, or sweat rate after whole body heating. These data suggest that vestibular activation by head movements is not a nonthermal factor affecting SSNA and cutaneous end-organ responses in humans.

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Section: Discussionmentioning

confidence: 95%

“…Heating also has direct effects on endolymph and vestibular hair cell-firing characteristics (22,35,40). Therefore, it is possible that elevations in body temperature will alter afferent feedback from the vestibular sensory organs, modifying autonomic responses.…”

mentioning

confidence: 99%

Vestibular activation does not influence skin sympathetic nerve responses during whole body heating

Wilson

Kuipers²,

McHugh³

et al. 2004

Journal of Applied Physiology

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Three-dimensional spatial characteristics of caloric nystagmus

Haslwanter

Fetter

et al. 2000

Exp Brain Res

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We investigated the three-dimensional spatial characteristics of caloric nystagmus during excitation and inhibition of the lateral semicircular canal in five normal human subjects. Each subject was repositioned in 45 degrees steps at 1-min intervals such that the right lateral semicircular canal plane was reoriented in pitch, from 135 degrees backwards from the upright position to 135 degrees forwards, while the right ear was continuously stimulated with air at 44 degrees C. In orientations in which caloric stimulus resulted in excitation of the right lateral semicircular canal, the eye velocity axis was orthogonal to the average orientation of the right lateral semicircular canal plane. However, in orientations in which caloric stimulus resulted in inhibition of the right lateral semicircular canal, the eye velocity axis was orthogonal to the average orientation of the left and not the right lateral semicircular canal plane. These findings suggest that velocity and direction of caloric nystagmus depend not only on the absolute magnitude of vestibular activity on the stimulated side but also on the differences in activity between the left and right vestibular nuclei, most probably mediated centrally via brainstem commissural pathways.

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Core Body Temperature Effects on the Mouse Vestibulo-ocular Reflex

Hübner

Khan

Lasker

et al. 2017

JARO

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Core body temperature has been shown to affect vestibular end-organ and nerve afferents so that their resting discharge rate and sensitivity increase with temperature. Our aim was to determine whether these changes observed in extracellular nerve recordings of anaesthetized C57BL/6 mice corresponded to changes in the behavioural vestibulo-ocular reflex (VOR) of alert mice. The VOR drives eye rotations to keep images stable on the retina during head movements. We measured the VOR gain (eye velocity/head velocity) and phase (delay between vestibular stimulus and response) during whole-body sinusoidal rotations ranging 0.5-12 Hz with peak velocity 50 or 100 °/s in nine adult C57BL/6 mice. We also measured the VOR during whole-body transient rotations with acceleration 3000 or 6000 °/s reaching a plateau of 150 or 300 °/s. These measures were obtained while the mouse's core body temperature was held at either 32 or 37 °C for at least 35 min before recording. The temperature presentation order and timing were pseudo-randomized. We found that a temperature increase from 32 to 37 °C caused a significant increase in sinusoidal VOR gain of 17 % (P < 0.001). Temperature had no other effects on the behavioural VOR. Our data suggest that temperature effects on regularly firing afferents best correspond to the changes that we observed in the VOR gain.

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Direct Influence of Temperature on the Semicircular Canal Receptor

Cited by 7 publications

References 11 publications

Vestibular activation does not influence skin sympathetic nerve responses during whole body heating

Vestibular activation does not influence skin sympathetic nerve responses during whole body heating

Three-dimensional spatial characteristics of caloric nystagmus

Core Body Temperature Effects on the Mouse Vestibulo-ocular Reflex

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