Direct In Vitro Effects of Androgens and Estrogens on &lt;E1&gt;ob&lt;/E1&gt; Gene Expression and Leptin Secretion in Human Adipose Tissue

Machinal-Quélin, Florence; Dieudonné, Marie‐Noëlle; Pecquery, René; Leneveu, Marie-Christine; Giudicelli, Yves

doi:10.1385/endo:18:2:179

Cited by 95 publications

(66 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In monkeys, DHEA(S) has a circadian rhythm, characterized by a morning peak, which is in antiphase with the circadian plasma leptin rhythm (Downs et al 2001, Urbanski et al 2004. Furthermore, DHEA(S) is a precursor to testosterone, and previous work has shown that androgens such as testosterone can inhibit the release of leptin (Elbers et al 1997, Jockenhovel et al 1997, Wabitsch et al 1997, Machinal-Quélin et al 2002. Therefore, it is plausible that the absence of a circadian leptin rhythm in the old peri-and post-menopausal females, stems from a loss of androgenmediated leptin inhibition via DHEA(S).…”

Section: Discussionmentioning

confidence: 99%

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Downs

Urbanski

2006

Journal of Endocrinology

View full text Add to dashboard Cite

The adipocyte-derived hormone leptin plays a pivotal role in the regulation of body weight and energy homeostasis. Many studies have indicated that the circulating levels of leptin show a 24-h rhythm, but the exact cause and nature of this rhythm is still unclear. In the present study, we remotely collected blood samples every hour from young and old, male and female rhesus monkeys, and examined their 24-h plasma leptin profiles. In both the young males (10-11 years) and females (7-13 years), a clear 24-h plasma leptin rhythm was evident with a peak occurring w4 h into the night and a nadir occurring w1 h into the day (lights on from 0700 to 1900 h). A 24-h plasma leptin rhythm was also observed in the old males (23-30 years), even when they were maintained under constant lighting conditions (continuous dim illumination of w100 lx). In marked contrast, plasma leptin concentrations were relatively constant across the day and night in old peri-and post-menopausal females (17-24 years), regardless of the lighting schedule. These data establish that rhesus monkeys, like humans, show a daily nocturnal rise in plasma leptin, and the magnitude of this rhythm undergoes a sex-specific aging-dependent attenuation. Furthermore, they suggest that the underlying endocrine mechanism may be driven in part by a circadian clock mechanism.

show abstract

Section: Discussionmentioning

confidence: 99%

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Downs

Urbanski

2006

Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Both the long and short forms were shown to be present in a nonmalignant human breast epithelial cell line (Hu et al 2002) and some human breast cancer cell lines (Dieudonne et al 2002, Hu et al 2002, Laud et al 2002, Frankenberry et al 2006, indicating the potential for a paracrine mitotic interaction between leptin synthesized by the surrounding adipocytes and the target mammary cells. Laud et al (2002) reported that both forms occur in the ER-positive MCF-7 and T47D human breast cancer cell lines; they were also present in the epithelial cells of all of 20 primary breast cancers, only 5 of which were ER-positive.…”

Section: Leptinmentioning

confidence: 99%

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

Vona-Davis

Rose²

2007

Endocr Relat Cancer

443

359

View full text Add to dashboard Cite

Adipokines (leptin, adiponectin, and hepatocyte growth factor (HGF)) secreted from adipose tissue have come to be recognized for their contribution to the mechanisms by which obesity and related metabolic disorders influence breast cancer risk. In this review, we discuss the direct and indirect effects of these protein factors on the biological and clinical aspects of breast cancer biology, and emphasize their distinctive modes of action through endocrine-, paracrine-, and autocrine-mediated pathways. The stimulatory effects of leptin on breast cancer growth were considered to occur primarily via activation of the estrogen receptor; however, new evidence suggests that leptin may be acting on downstream cell signaling pathways in both estrogendependent and -independent cell types. Another secretory adipokine, HGF, may act largely not only to promote tumor cell invasion, but also to enhance tumor growth indirectly by stimulating angiogenesis. In contrast, adiponectin, an endogenous insulin sensitizer, exerts a direct growthinhibitory effect on tumor cells by downregulating cell proliferation and upregulating apoptosis, and also inhibits tumor-related angiogenesis.

show abstract

“…Moleküler çalışmalar her iki hormonun "sinyal ileticisi ve transkripsiyon 3 aktivatörü (STAT3)" üzerine etkilerinin olduğunu ve östrojenin leptin kaynaklı STAT3 fosforilasyonunu arttırdığını göstermiştir. 28,29 Çalışmamızda ise BKİ ve BKİSDS değerleri birbirine yakın, PT grubunun leptin konsantrasyonları sağlıklı kontrol grubuna göre daha düşük bulunmuştur. Bu sonuçlar, antropometrik parametreler ne olursa olsun çevresel, genetik veya beslenme alışkanlıkları gibi diğer nedenlerin leptin düzeylerini etkilediğini düşündürmektedir.…”

Section: Discussionunclassified

Obesity Associated Adipocytokines in Girls with Premature Thelarche

İlhan¹,

Çetin²

2016

Turkiye Klinikleri J Pediatr

View full text Add to dashboard Cite

iğer puberte bulguları (hızlandırılmış büyüme hızı, gelişmiş kemik olgunlaşması, aksiller ve kasık kıllanması) olmaksızın sekiz yaşın-dan önce meme gelişiminin ortaya çıkması prematür telarş (PT) olaTurkiye Klinikleri J Pediatr 2016;25 (1) 1 Prematür Telarşlı Çocuklarda Obezite İlişkili Adipositokinler Ö ÖZ ZE ET T A Am ma aç ç: : Prematür telarş, sekiz yaşından küçük kız çocuklarında herhangi bir ek cinsel gelişim belirtileri olmadan meme dokusunun erkenden büyümesi ile karakterize bir tablodur. Son yıllarda, pubertenin erkene kayması ve pubertal bulguların erken yaşta görülmesinde obezite, hormon bazlı yiyeceklerin alımı ve çevre-sel/sosyal değişikliklerin rol oynadığı öne sürülmektedir. Bu çalışmanın amacı, fizyopatolojisi halen kesin olarak bilinmeyen prematür telarş hastalığını obezite ile ilişkili adipositokinler açısından değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Hasta grubu alışılmadık meme gelişimi şikâyeti ile çocuk endokrinoloji polikliniğine getirilen ve yaşları üç-sekiz arasında değişen 19 kız hastadan, kontrol grubu ise aynı yaş aralığındaki 17 sağlıklı kızdan oluşturuldu. Beden kitle indeksi Türk referans değerlerine, meme gelişimi Tanner evreleme yönte-mine göre değerlendirildi. Folikül uyarıcı hormon (FSH), luteinizan hormon (LH), östradiol (E2) seviyeleri immünokemiluminometrik, obezite ile ilişkili yağ doku adipositokinlerinden leptin, adiponektin, nesfatin-1, apelin-36, Tümör nekrozis faktör-alfa (TNF-α) ve rezistin düzeyleri ise ELISA yöntemi ile değerlendirildi. B Bu ul lg gu ul la ar r: : Hasta grubunun E2 ve LH düzeyleri kontrollere göre farklılık göstermez iken, FSH düzeyleri istatistiksel olarak anlamlı yüksek bulundu. Serum leptin ve rezistin düzeyleri kontrollere göre anlamlı düşük iken, apelin-36 ve nesfatin-1 düzeyleri istatistiksel olarak anlamlı yüksek bulunurken, TNF-α ve adiponektin düzeylerinde ise anlamlı bir farklılık saptanamadı. S So on nu uç ç: : Prematür telarş hastalığında bilinen klasik hormonal kontrol dışında yeni tanımlanmış hormon ve sinyal molekülleri gibi hastalığın fizyopatolojisi üzerine etkili çeşitli faktörler de etkili rol alabilmektedir. Ancak, hastalıktan sorumlu esas mekanizmanın belirlenebilmesi için daha detaylı çalışmaların yapılmasına ihtiyaç vardır.A An na ah ht ta ar r K Ke el li im me el le er r: : Leptin; adiponektin; tümör nekroze edici faktör-alfa; meme; büyüme ve gelişim A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Premature thelarche is defined as the onset of breast development without any additional signs of sexual maturation in girls younger than eight years. In recent years, obesity, hormone-based foods intake, environmental/social change are proposed to play a role in early puberty and the signs of puberty at an early age. The aim of the present study was to evaluate in terms of adipocytokines associated with obesity in premature telarche, which is exact pathophysiology of the disease is still unknown. M Ma at te er ri ia al l a an nd d M Me et th h--o od ds s: : The patient group included 19 girls...

show abstract

Direct In Vitro Effects of Androgens and Estrogens on <E1>ob</E1> Gene Expression and Leptin Secretion in Human Adipose Tissue

Cited by 95 publications

References 43 publications

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Aging-related sex-dependent loss of the circulating leptin 24-h rhythm in the rhesus monkey

Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression

Obesity Associated Adipocytokines in Girls with Premature Thelarche

Contact Info

Product

Resources

About