Direct immunofluorescence in the diagnosis of oral mucosal diseases

Kilpi, Anu; Rich, Alison M.; Radden, B. G.; Reade, Peter C.

doi:10.1016/s0901-5027(88)80219-4

Cited by 18 publications

(15 citation statements)

References 11 publications

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“…CBs within the epithelium or within the superficial connective tissue, which stain with any combination of antifibrinogen, anti-C3, or anti-Ig, may or may not be present. 17 In our study, the positive yield of DIF was 75%, whereas, in previous studies, the positive yield of DIF in LP cases (mostly from oral LP cases) was in the range 37-97%. [3][4][5]7,8,11 In most previous studies, the specimens were derived from the oral mucosa; however, Annessi et al .…”

Section: Discussioncontrasting

confidence: 75%

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Direct immunofluorescence study in patients with lichen planus

et al. 2007

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This study showed that the positive yield of DIF in LP was 75%. Shaggy fibrin deposition at the DEJ, which is the single best indicator in the diagnosis of LP, was found in 56% of cases. The presence of CBs only, which is a poorer indicator than the shaggy deposition of fibrin along the DEJ, was found in 22% of cases. There were no statistically significant differences in positive DIF yield between specimens derived from glabrous skin and oral lesions (P = 0.67). Forty-four per cent of cases had immunoreactants other than fibrin deposited along the DEJ, which resembled those of LE.

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Section: Discussioncontrasting

confidence: 75%

“…Less commonly, anti‐C3 may be seen in a faint, fine, granular or discontinuous linear pattern in this region. CBs within the epithelium or within the superficial connective tissue, which stain with any combination of antifibrinogen, anti‐C3, or anti‐Ig, may or may not be present 17 …”

Section: Discussionmentioning

confidence: 99%

Direct immunofluorescence study in patients with lichen planus

et al. 2007

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“…In epidermolysis bullosa there is the presence of bullous skin lesions and it is an inherited disorder which begins at birth or soon after. The presence of IgA deposits (linear and granular patterns) along the basement membrane zone in the perilesional tissue helps to distinguish Linear IgA disease and dermatitis herpetiformis (DH) from ABH 12 13. In DH oral manifestations are uncommon but erythematous erosions; purpura and pseudovesicular lesions have been reported.…”

Section: Discussionmentioning

confidence: 99%

Angina bullosa haemorrhagica

2013

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SUMMARYA woman in her early 40s presented with a painless ulceration on the right side of the posterior palate, she had an earlier history of similar lesions after the rupturing of blood filled blisters in the oral cavity. On examination, a diffuse erythematous area and ulcers covered with necrotic slough were noticed on the right and left side of the posterior palate and on the right buccal mucosa. On follow-up visit, a large blood filled blister was noticed in the buccal vestibule. We advised routine haematological investigations to rule out any bleeding disorders and direct immunofluorescence of the affected tissue and perilesional areas to rule out autoimmune blistering conditions. Haematological investigations revealed no abnormalities and immunofluorescence testing was negative. A diagnosis of angina bullosa haemorrhagica was made by excluding all other conditions. Symptomatic treatment was given, patient was educated about the condition and reassured. BACKGROUND

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“…[1,2,[5][6][7]10,11] Previous studies proposed that CB was usually detected in interface dermatitis and might increase the index of suspicion for LE and LP. [7] Interestingly, our study showed that CB was commonly detected in interface dermatitis and vasculitis.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic significance of colloid body deposition in direct immunofluorescence

Chularojanamontri¹,

Tuchinda²,

Triwongwaranat³

et al. 2010

Indian J Dermatol Venereol Leprol

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Immunoreactant deposits at CB alone can be found in various diseases but a strong intensity and high quantity favor the diagnosis of interface dermatitis. CB plus dermoepidermal junction (DEJ) deposits are more common in interface dermatitis than any other disease. Between lichen planus (LP) and discoid lupus erythematosus (DLE), CB alone is more common in LP; whereas, CB plus DEJ and superficial blood vessel (SBV) is more common in DLE. The most common pattern in both diseases is CB plus DEJ. The quantity and intensity of CB in LP is higher than in DLE.

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Direct immunofluorescence in the diagnosis of oral mucosal diseases

Cited by 18 publications

References 11 publications

Direct immunofluorescence study in patients with lichen planus

Direct immunofluorescence study in patients with lichen planus

Angina bullosa haemorrhagica

Diagnostic significance of colloid body deposition in direct immunofluorescence

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