Direct imaging of transient interference in a single-mode waveguide using near-field scanning optical microscopy

Yuan, Guangwei; Stephens, Matthew D.; Dandy, David S.; Lear, K.L.

doi:10.1109/lpt.2005.858151

Cited by 18 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase of effective refractive index above the waveguide due to an increase in nanobiofilm thickness causes the evanescent field distribution to shift upwards into the nanobiofilm, which decreases the photocurrent through the buried detector. 6 The field shift mechanism, in a proofof-concept configuration without buried detector arrays, was validated with near field scanning optical microscopy on inorganic adlayers, 7 photoresist, 8 and different concentrations of C-reactive protein. 9 The LEAC sensor with buried detector arrays has been tested using patterned single layer organic films, including photoresist and bovine serum albumin ͑BSA͒.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Waveguide biosensor with integrated detector array for tuberculosis testing

Yan

Lynn

Kingry

et al. 2011

Applied Physics Letters

View full text Add to dashboard Cite

A label-free immunoassay using a local evanescent array coupled ͑LEAC͒ biosensor is reported. Complementary metal oxide semiconductor chips with integrated photoconductor arrays are used to detect an antibody to a M. tuberculosis protein antigen, HspX. The metrology limits of the LEAC sensor using dc and ac measurement systems correspond to average film thicknesses of 28 and 14 pm, respectively. Limits of detection are 87 and 108 pm, respectively, for mouse immunoglobulin G antibody patterning and antigen detection.

show abstract

mentioning

confidence: 99%

“…The average sensitivity S of the LEAC sensor with a core thickness of 100 nm used in this experiment is 16%/nm as determined from previous experiments and simulations. 7 The metrology limit ͑t-value ϫ SE oe ͒ is 0.46% for dc measurement, corresponding to 28 pm.…”

mentioning

confidence: 99%

Waveguide biosensor with integrated detector array for tuberculosis testing

Yan

Lynn

Kingry

et al. 2011

Applied Physics Letters

View full text Add to dashboard Cite

show abstract

CMOS optoelectronic components for clock distribution

Pownall

Thangaraj

Yuan

et al. 2010

Microelectronic Engineering

View full text Add to dashboard Cite

Optical and physical characterization of a local evanescent array coupled biosensor: Use of evanescent field perturbations for multianalyte sensing

Stephens

Yuan

Lear

et al. 2010

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

The evanescent field surrounding the core of an optical waveguide is very sensitive to refractive index changes near the core. This sensitivity can be exploited to form the basis for a quantitative sensor with high specificity and sensitivity. Selective probe molecules may be attached to the surface of a waveguide core and the evanescent field locally monitored as target analytes are introduced to the system. In this study, probe/analyte regions were simulated using lithographically patterned organic films with thicknesses of 60 nm and 130 nm. The evanescent field strength was measured quantitatively using near field scanning optical microscopy (NSOM). The presence of the organic material on the waveguide caused up to a 70% change in the intensity of the evanescent field over the patterned region and the excitation of a weakly bound higher order mode. The waveguide core and surrounding cladding were numerically simulated using the beam propagation method and these predictions are in quantitative agreement with the experimental results obtained using NSOM.

show abstract

Direct imaging of transient interference in a single-mode waveguide using near-field scanning optical microscopy

Abstract: Index Terms-Biosensor, evanescent field, leaky mode, near-field scanning optical microscopy (NSOM), optical interference, waveguide.

Cited by 18 publications

References 7 publications

Waveguide biosensor with integrated detector array for tuberculosis testing

Waveguide biosensor with integrated detector array for tuberculosis testing

CMOS optoelectronic components for clock distribution

Optical and physical characterization of a local evanescent array coupled biosensor: Use of evanescent field perturbations for multianalyte sensing

Contact Info

Product

Resources

About