Direct High‐Frequency Stimulation of Peri‐Implant Rabbit Bone: A Pilot Study

Zhang, Xiaolei; Naert, Ignace; Schoonhoven, Dorien Van; Duyck, Joke

doi:10.1111/j.1708-8208.2010.00298.x

Cited by 5 publications

(7 citation statements)

References 37 publications

(69 reference statements)

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“…However, the 40 Hz group showed a slight decrease in the BS/TS ratio. In earlier studies, whole‐body LMHF vibration promoted osseointegration, local LMHF vibration promoted osseointegration, and low‐frequency 1‐Hz microvibration loaded directly on the implant in the rabbit tibia and beagle mandible increased the BIC . However, direct LMHF (8, 40, and 60 Hz) vibration did not yield any change in osseointegration …”

Section: Discussionmentioning

confidence: 86%

“…Although early studies showed that whole‐body LMHF vibration promoted both bone formation and peri‐implant bone formation, it remains unclear how the alveolar bone reacts when the LMHF vibration is locally and directly applied to the implant. Local axial vibrations (0.5 N, 40 Hz; and 20 N, 2 Hz) increased the BF around the implants . Low‐frequency (1 Hz) microvibration applied directly to titanium implants in rabbit femurs and tibiae increased bone ingrowth, bone volume, volumetric density, and bone formation, whereas the direct application of 1 Hz microvibration in beagle mandibles increased the bone density around the implant .…”

Section: Discussionmentioning

confidence: 99%

“…Local axial vibrations (0.5 N, 40 Hz; and 20 N, 2 Hz) increased the BF around the implants. 24 Low-frequency (1 Hz) microvibration applied directly to titanium implants in rabbit femurs and tibiae increased bone ingrowth, bone volume, volumetric density, and bone formation, 39,40 whereas the direct application of 1 Hz microvibration in beagle mandibles increased the bone density around the implant. 41 However, when the LMHF vibration was directly loaded on the implant, neither the 60 Hz vibration on the rabbit tibiae nor the 40 Hz or 80 Hz vibration on the rat tibiae altered the BF.…”

Section: Discussionmentioning

confidence: 99%

“…Local axial vibrations (0.5 N, 40 Hz; and 20 N, 2 Hz) on Wistar rat tibiae for 4 weeks (10 minutes per day) increased the BIC and BF around the implants. 24 However, when the LMHF vibration was directly loaded on the implant, none of the treatments (40, 60, or 80 Hz) on rat tibiae altered the BIC or BF 25,26 (they did, over 40 should cause failure).…”

Section: Introductionmentioning

confidence: 97%

See 3 more Smart Citations

Direct Radial LMHF Microvibration Induced Bone Formation and Promoted Implant Osseointegration

Wang

Liu

Tang

et al. 2014

Clin Implant Dent Rel Res

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Direct Radial LMHF Microvibration Induced Bone Formation and Promoted Implant Osseointegration

Wang

Liu

Tang

et al. 2014

Clin Implant Dent Rel Res

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show abstract

“…Vibration may activate mechanosensitive cells through mechanical deformation of the plasma membrane [Uzer et al, ] and can elicit a high degree of muscle activation through the tonic vibration reflex [Roelants et al, ]. Local axial vibrations (60 Hz) on Wistar rat tibiae for 4 weeks (10 min/day, 5 days/week) were shown to increase bone volume around tibial implants [Zhang et al, ]. However, the mechanisms by which vibrational loading may stimulate bone formation are not known, and relatively few studies have been conducted to examine the effect of local vibration training on bone metabolism in rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of local vibration and pulsed electromagnetic field on bone fracture: A comparative study

Bilgin

Çelik

Gem

et al. 2017

Bioelectromagnetics

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The effectiveness of various therapeutic methods on bone fracture has been demonstrated in several studies. In the present study, we tried to evaluate the effect of local low-magnitude, high-frequency vibration (LMHFV) on rat tibia fracture in comparison with pulsed electromagnetic fields (PEMF) during the healing process. Mid-diaphysis tibiae fractures were induced in 30 Sprague-Dawley rats. The rats were assigned into groups such as control (CONT), LMHFV (15 min/day, 7 days/week), and PEMF (3.5 h/day, 7 days/week) for a three-week treatment. Nothing was applied to control group. Radiographs, serum osteocalcin levels, and stereological bone analyses of the three groups were compared. The X-rays of tibiae were taken 21 days after the end of the healing process. PEMF and LMHFV groups had more callus formation when compared to CONT group; however, the difference was not statistically significant (P = 0.375). Serum osteocalcin levels were elevated in the experimental groups compared to CONT (P ≤ 0.001). Stereological tests also showed higher osteogenic results in experimental groups, especially in LMHFV group. The results of the present study suggest that application of direct local LMHFV on fracture has promoted bone formation, showing great potential in improving fracture outcome. Bioelectromagnetics. 38:339-348, 2017. © 2017 Wiley Periodicals, Inc.

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In vivoassessment of the effect of controlled high- and low-frequency mechanical loading on peri-implant bone healing

Zhang

Vandamme

Torcasio

et al. 2012

J. R. Soc. Interface.

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The aim of this study was to investigate the effect of controlled high-(HF) and low-frequency (LF) mechanical loading on peri-implant bone healing. Custom-made titanium implants were inserted in both tibiae of 69 adult Wistar rats. For every animal, one implant was loaded by compression through the axis of tibia (test), whereas the other one was unloaded (control). The test implants were randomly distributed among four groups receiving different loading regimes, which were determined by ex vivo calibration. Within the HF (40 Hz) or LF (2 Hz) loading category, the magnitudes were chosen as low-(LM) and high-magnitude (HM), respectively, leading to constant strain rate amplitudes for the two frequency groups. This resulted in the four loading regimes: (i) HF-LM (40 Hz-0.5 N); (ii) HF-HM (40 Hz -1 N); (iii) LF-LM (2 Hz -10 N); and (iv) LF-HM (2 Hz -20 N) loading. Loading was performed five times per week and lasted for one or four weeks. Tissue samples were processed for histology and histomorphometry (bone-to-implant contact, BIC; and peri-implant bone fraction, BF) at the cortical and medullar level. Data were analysed statistically with ANOVA and paired t-tests with the significance level set at 0.05. For the one-week experiments, an increased BF adjacent to the implant surface at the cortical level was exclusively induced by the LF-HM loading regime (2 Hz-20 N). Four weeks of loading resulted in a significant effect on BIC (and not on BF) in case of HF-LM loading (40 Hz -0.5 N) and LF-HM loading (2 Hz -20 N): BIC at the cortical level significantly increased under both loading regimes, whereas BIC at the medullar level was positively influenced only in case of HF-LM loading. Mechanical loading at both HF and LF affects osseointegration and peri-implant BF. Higher loading magnitudes (and accompanying elevated tissue strains) are required under LF loading to provoke a positive peri-implant bone response, compared with HF loading. A sustained period of loading at HF is needed to result in an overall enhanced osseointegration.

show abstract

Direct High‐Frequency Stimulation of Peri‐Implant Rabbit Bone: A Pilot Study

Abstract: Histomorphometric analyses could not reveal a pronounced effect of direct immediate high-frequency implant loading.

Cited by 5 publications

References 37 publications

Direct Radial LMHF Microvibration Induced Bone Formation and Promoted Implant Osseointegration

Direct Radial LMHF Microvibration Induced Bone Formation and Promoted Implant Osseointegration

Effects of local vibration and pulsed electromagnetic field on bone fracture: A comparative study

In vivoassessment of the effect of controlled high- and low-frequency mechanical loading on peri-implant bone healing

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