Direct genetic and maternal influences on behavior and growth in two inbred mouse strains

Abeelen, J. H. F. van

doi:10.1007/bf01066223

Cited by 18 publications

(2 citation statements)

References 10 publications

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“…Postnatal effects on the amplitude of the ASR were also found in other studies on mice and rats (van Abeelen 1980;Gomez-Serrano et al 2001), however, in these studies the ASR of the pups was changed in direction of the foster mother. In another study, postnatal maternal factors influenced the ASR in mGluR5 KO mice derived from homozygous and heterozygous matings, although possible influences of the uterine environment were not studied (Brody and Geyer 2004).…”

Section: Uterine and Postnatal Effectsmentioning

confidence: 56%

Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

et al. 2008

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In the present study, reciprocal embryo transfers were conducted to examine genetic and maternal effects on the baseline and fear-sensitized acoustic startle response (ASR) in the two inbred strains C3H/HeN and DBA/2JHd and the outbred strain NMRI. The largest differences in the ASR were found in untreated strains (effect size 0.6). The transfer procedure per se had a significant effect on the behavior of NMRI mice resulting in a reduction in the baseline, and an increase in the fear-sensitized ASR. In contrast, there were no significant effects of the transfer procedure in the two inbred strains. Autosomal genetic effects had a stronger impact on the amplitude of the ASR (effect sizes 0.5) than sex (effect sizes 0.06) as revealed by reciprocal embryo transfer. Nevertheless, the genetic effects on the fear-sensitized ASR were somewhat more variable and strain-dependent (effect sizes 0.1-0.2). Global maternal effects were detected after embryo transfer into NMRI mothers resulting in a larger reduction of the ASR in the offspring of DBA and NMRI donors than C3H donors (effect sizes 0.1-0.2). An additional fostering procedure was introduced to dissect uterine and postnatal maternal effects in NMRI offspring. Uterine factors changed the baseline ASR of the offspring in direction of the recipient mother strain. Surprisingly, postnatal maternal effects on the ASR were contrary to the behavior of the rearing mother. In conclusion, both genetic and prenatal/postnatal maternal factors persistently influenced the ASR of the offspring, whereas the fear-sensitized ASR was mainly influenced by genetic factors. Our study shows that uterine and postnatal maternal influences deserve more attention when determining the phenotype of genetically engineered mice at least in the first generation following embryo transfer.

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Section: Uterine and Postnatal Effectsmentioning

confidence: 56%

Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

et al. 2008

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“…Thigmotaxis is known to exhibit large interstrain differences in mice (e.g., Fredericson, 1953; Gershenfeld & Paul, 1997); hence, it is plausible to assume that it is, at least to a certain degree, genetically determined. In species requiring maternal care, however, parental behavior often influences the behavior of the offspring and, consequently, the emotional behavior of fostered mice may be dependent on the strain of their host mother (Calatayud & Belzung, 2001; Le Pape & Lassalle, 1984; van Abeelen, 1980; see also Russell, 1971). Comparison of the behavior of pups infostered by mothers from their own strain and of pups crossfostered by mothers from another strain provides a tool for separating the effects of postnatal maternal care from the hypothesized genetic effects on behavior (Le Pape & Lassalle, 1984).…”

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confidence: 99%

Crossfostering in mice selectively bred for high and low levels of open‐field thigmotaxis

Leppänen

Ewalds-Kvist

2005

Scandinavian J Psychology

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The main purpose of this research was to investigate whether the difference in open-field (OF) thigmotaxis between mice selectively bred for high and low levels of wall-seeking behavior originated from genetic or acquired sources. Unfostered, infostered, and crossfostered mice were compared in two experiments in which the effects of strain, sex, and fostering on ambulation, defecation, exploration, grooming, latency to move, radial latency, rearing, thigmotaxis, and urination were studied. These experiments revealed that OF thigmotaxis was unaffected by the foster condition and thus genetically determined. The selected strains of mice also diverged repeatedly with regard to exploration and rearing. The findings are in line with the previously described existence of an inverse relationship between emotionality and exploration.

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Behavioural effects of (-)naloxone in mice from four inbred strains

Gorris

Abeelen

1981

Psychopharmacology

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To study the role of endogenous opioid peptides in the regulation of behavioural responses to novelty, male mice from the inbred strains SRH, SRL, C57BL/6, and DBA/2 were injected IP with either saline alone, or the opiate antagonist naloxone, dissolved in saline, in dosages of 4 or 8 mg/kg. After 10 min, the animals were placed individually for 20 min in a novel environment and some 12 behavioural components were recorded. Naloxone reduced grooming and incipient rearing in all four strains and it reduced sniffing, leaning against the wall, and locomotor activity in some of them. Object-sniffing, object-learning, defecation, freezing, and Straub tail elevation remained unaffected. The results for grooming and locomotor activity are largely in agreement with reports from others. Rather unexpectedly, the drug enhanced rearing responses in all strains. Although in several cases, a genotype-treatment interaction became apparent, the observed strain differences usually persisted and the correlations found between the behavioural components did not alter much. The naloxone-induced reductions in sniffing, leaning, locomotion, and grooming suggest endogenous opioid involvement in the control of behavioural activation in a novel situation. The increases in rearing possibly result from an additional agonist action of naloxone.

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Direct genetic and maternal influences on behavior and growth in two inbred mouse strains

Cited by 18 publications

References 10 publications

Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer

Crossfostering in mice selectively bred for high and low levels of open‐field thigmotaxis

Behavioural effects of (-)naloxone in mice from four inbred strains

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