Direct evidence of lipid transport by the Drs2–Cdc50 flippase upon truncation of its terminal regions
Sara Abad Herrera,
Bo Højen Justesen,
Thibaud Dieudonné
et al.
Abstract:P4‐ATPases in complex with Cdc50 subunits are lipid flippases that couple ATP hydrolysis with lipid transport to the cytoplasmic leaflet of membranes to create lipid asymmetry. Such vectorial transport has been shown to contribute to vesicle formation in the late secretory pathway. Some flippases are regulated by autoinhibitory regions that can be destabilized by protein kinase‐mediated phosphorylation and possibly by binding of cytosolic proteins. In addition, the binding of lipids to flippases may also induc… Show more
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