1993
DOI: 10.1007/bf02269695
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Direct enantiomeric analysis of amphetamine in plasma by simultaneous solid phase extraction and chiral derivatization

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Cited by 36 publications
(9 citation statements)
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“…Another advantage over other LC indirect methods [14,15] is that derivatizations with OPA-NAC do not produce kinetic differentiation between the enantiomers. Another advantage over other LC indirect methods [14,15] is that derivatizations with OPA-NAC do not produce kinetic differentiation between the enantiomers.…”
Section: Discussionmentioning
confidence: 99%
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“…Another advantage over other LC indirect methods [14,15] is that derivatizations with OPA-NAC do not produce kinetic differentiation between the enantiomers. Another advantage over other LC indirect methods [14,15] is that derivatizations with OPA-NAC do not produce kinetic differentiation between the enantiomers.…”
Section: Discussionmentioning
confidence: 99%
“…the reported methods using derivatization with chiral reagents, the reaction times are typically 10 60 min [1,11,12,14,15], but even overnight periods have been used to form the diastereomers [13]. 0 Finally, as a basic medium is necessary to form the isoindoles, the effect of the pH of the reaction was tested.…”
mentioning
confidence: 99%
“…The cost of chiral columns increases considerably at the semi-preparative and preparative scales. As an alternative to the use of chiral columns, enantiomeric pairs of methylbenzylamine, naphthylethylamine (Chou et al, 1989), amphetamine, ephedrine and pseudoepherine Zhou and Krull et al, 1993;Hernandez et al, 1998) have been separated on reversed-phase C 18 columns after derivatisation with Fmoc-L-proline forming Fmoc-L-Pro-amine diastereomers. More recently, we isolated milligram quantities of the enantiomers of ammodendrine and anabasine from extracts of L. formosus and N. glauca using semi-preparative and preparative reversed phase C 18 chromatography after conversion to their Fmoc-L-Alaammodendrine and Fmoc-L-Ala-anabasine diastereomers (Lee et al, 2005(Lee et al, , 2006.…”
Section: Introductionmentioning
confidence: 99%
“…Liquid chromatography (LC) and capillary electrophoresis (CE) have been applied for the determination of amphetamine in biological fluids, either directly or after derivatization 4–13. LC/electrospray mass spectrometry (LC/ES‐MS) has emerged as a sensitive analytical technique for the determination of various compounds 14–18.…”
mentioning
confidence: 99%