-Although the synthesis of symmetrical dual-band bandpass filters has been studied in the literature, very little seems to be known about the general asymmetrical case. In this paper, a procedure for the synthesis of asymmetrical dual-band bandpass filters implemented with in-line dual-mode cavities is proposed. The latter starts with the determination of a filtering characteristic fulfilling the electrical specifications in the spectral domain by means of an optimization scheme. As to the coupling topology, the in-line architecture that is intended for the hardware realisation, as well as the asymmetrical nature of the response, lead naturally to the choice of an extended box topology or its variants. It was recently shown that these topologies possess the property of multiple solutions, meaning that the related coupling matrix synthesis problem admits several solutions. On one hand, this multiplicity offers some additional flexibility to the designer, but on the other hand, working with multiple solutions may lead to ambiguities during the tuning process. Our procedure takes the best of both worlds : after an exhaustive synthesis step yielding a list of equivalent coupling matrices, simplifications of the original topology are obtained by cancelling some particular couplings. The locations of cancelled couplings are chosen so as to preserve the electrical response and to provide some important hardware simplifications. It is also shown that the resulting simplified coupling topology no longer has the multiple solution property, solving ambiguity problems that might occur during the tuning step. The procedure is demonstrated on two examples of 11-pole asymmetrical dual-band bandpass filters. A numerical model driven by a coupling matrix extraction process is used to determine the geometrical dimensions. Finally an experimental prototype is built in order to validate our design approach.