Direct electrodeposion of reduced graphene oxide and dendritic copper nanoclusters on glassy carbon electrode for electrochemical detection of nitrite

Zhang, Di; Fang, Yuxin; Miao, Zhiying; Ma, Min; Du, Xin; Takahashi, Satoshi; Anzai, Jun‐ichi; Chen, Qiang

doi:10.1016/j.electacta.2013.06.015

Cited by 143 publications

(49 citation statements)

References 45 publications

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“…We determined the detection limit to be 830 nM based on three standard deviations. The detection sensitivity of nitrite in the presence of EBC is comparable with values reported in the literature for nitrite content in various buffers [45][46][47] .…”

Section: Detection Of Nitrite In Clinical Ebc Samplessupporting

confidence: 74%

“…Nitrite oxidation-based methods with a final product of NO 3 are usually preferred because the presence of interfering molecules (such as oxygen) during reduction can be avoided 33 . However, an oxidation reaction as the basis for detecting nitrite requires a high over-potential 34 ; thus, in recent years, many attempts have been made to develop novel electrode materials [35][36][37][38][39][40][41][42][43][44][45][46][47][48] .…”

Section: Introductionmentioning

confidence: 99%

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Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide

et al. 2017

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We present a portable non-invasive approach for measuring indicators of inflammation and oxidative stress in the respiratory tract by quantifying a biomarker in exhaled breath condensate (EBC). We discuss the fabrication and characterization of a miniaturized electrochemical sensor for detecting nitrite content in EBC using reduced graphene oxide. The nitrite content in EBC has been demonstrated to be a promising biomarker of inflammation in the respiratory tract, particularly in asthma. We utilized the unique properties of reduced graphene oxide (rGO); specifically, the material is resilient to corrosion while exhibiting rapid electron transfer with electrolytes, thus allowing for highly sensitive electrochemical detection with minimal fouling. Our rGO sensor was housed in an electrochemical cell fabricated from polydimethyl siloxane (PDMS), which was necessary to analyze small EBC sample volumes. The sensor is capable of detecting nitrite at a low over-potential of 0.7 V with respect to an Ag/AgCl reference electrode. We characterized the performance of the sensors using standard nitrite/buffer solutions, nitrite spiked into EBC, and clinical EBC samples. The sensor demonstrated a sensitivity of 0.21 μA μM − 1 cm − 2 in the range of 20-100 μM and of 0.1 μA μM − 1 cm − 2 in the range of 100-1000 μM nitrite concentration and exhibited a low detection limit of 830 nM in the EBC matrix. To benchmark our platform, we tested our sensors using seven pre-characterized clinical EBC samples with concentrations ranging between 0.14 and 6.5 μM. This enzyme-free and label-free method of detecting biomarkers in EBC can pave the way for the development of portable breath analyzers for diagnosing and managing changes in respiratory inflammation and disease.

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Section: Detection Of Nitrite In Clinical Ebc Samplessupporting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide

et al. 2017

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“…Up to now, several graphene-based nanocomposites as precursors were applied to determine nitrite [28][29][30][31][32]. For example, Mani et al [30] used chemically reduced graphene oxide for the determination of nitrite and a narrow linear range of 8.9-167 M with a sensitivity of 26.7 A mM −1 was obtained.…”

mentioning

confidence: 99%

High quality Pt–graphene nanocomposites for efficient electrocatalytic nitrite sensing

Yang

Bin

Wang

et al. 2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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“…Many reports also pointed out that graphene could enhance the electrocatalytic performance of noble metal nanoparticles. 13,14 In recent times, as a typical nanomaterial, silver nanostructures are also studied for detecting DO. 9 Therefore, attempting to combine the graphene with Ag nanoparticles is expected to generate a suitable electrode material for DO sensing application.…”

Section: Introductionmentioning

confidence: 99%

Dissolved oxygen detection by galvanic displacement-induced graphene/silver nanocomposite

Zheng

Fu³

et al. 2015

Bull Mater Sci

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This paper proposed a simple, efficient and sensitive electrochemical sensor for dissolved oxygen (DO) detection based on a galvanic displacement synthesized reduced graphene oxide-silver nanoparticles (RGO/Ag) composite modified grassy carbon electrode (GCE). The synthesized RGO/Ag nanocomposite was characterized by UV-vis spectroscopy, Raman spectroscopy, scanning electron microscopy (SEM) and X-ray diffraction (XRD). The results indicate the graphene oxide (GO) has been successfully reduced during the galvanic displacement process and the average size of Ag nanoparticle is 52 nm. The RGO/Ag nanocomposite-modified GCE showed a significant enhancement of DO detection compared with bare and RGO-modified GCEs. Moreover, the proposed DO sensor also exhibited an excellent repeatability, reproducibility and anti-interference ability.

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Direct electrodeposion of reduced graphene oxide and dendritic copper nanoclusters on glassy carbon electrode for electrochemical detection of nitrite

Cited by 143 publications

References 45 publications

Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide

Toward point-of-care management of chronic respiratory conditions: Electrochemical sensing of nitrite content in exhaled breath condensate using reduced graphene oxide

High quality Pt–graphene nanocomposites for efficient electrocatalytic nitrite sensing

Dissolved oxygen detection by galvanic displacement-induced graphene/silver nanocomposite

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