Direct electrical stimulation mapping of cognitive functions in the human brain

Mahon, Bradford Z.; Miozzo, Michele; Pilcher, Webster H.

doi:10.1080/02643294.2019.1630375

Cited by 11 publications

(7 citation statements)

References 54 publications

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“…53,54 Direct electrical stimulation (DES) is the gold standard for identifying eloquent areas to maximize lesion resection and reduce new neurological deficits. [55][56][57] Relying solely on preoperative clinical information to determine the eloquent areas is associated with significant morbidity. 58 Only 6 studies (31.6%) used DES.…”

Section: Intraoperative Description Of Acmentioning

confidence: 99%

Awake Craniotomy in Africa: A Scoping Review of Literature and Proposed Solutions to Tackle Challenges

et al. 2023

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BACKGROUND: Awake craniotomy (AC) is a common neurosurgical procedure for the resection of lesions in eloquent brain areas, which has the advantage of avoiding general anesthesia to reduce associated complications and costs. A significant resource limitation in low- and middle-income countries constrains the usage of AC. OBJECTIVE: To review the published literature on AC in African countries, identify challenges, and propose pragmatic solutions by practicing neurosurgeons in Africa. METHODS: We conducted a scoping review under Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Scoping Review guidelines across 3 databases (PubMed, Scopus, and Web of Science). English articles investigating AC in Africa were included. RESULTS: Nineteen studies consisting of 396 patients were included. Egypt was the most represented country with 8 studies (42.1%), followed by Nigeria with 6 records (31.6%). Glioma was the most common lesion type, corresponding to 120 of 396 patients (30.3%), followed by epilepsy in 71 patients (17.9%). Awake-awake-awake was the most common protocol used in 7 studies (36.8%). Sixteen studies (84.2%) contained adult patients. The youngest reported AC patient was 11 years old, whereas the oldest one was 92. Nine studies (47.4%) reported infrastructure limitations for performing AC, including the lack of funding, intraoperative monitoring equipment, imaging, medications, and limited human resources. CONCLUSION: Despite many constraints, AC is being safely performed in low-resource settings. International collaborations among centers are a move forward, but adequate resources and management are essential to make AC an accessible procedure in many more African neurosurgical centers.

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Section: Intraoperative Description Of Acmentioning

confidence: 99%

Awake Craniotomy in Africa: A Scoping Review of Literature and Proposed Solutions to Tackle Challenges

et al. 2023

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“…Nevertheless, DES has found applications well beyond therapeutic neuromodulation. In particular, DES has been considered a gold standard for functional mapping of the brain for over a decade (Mandonnet et al, 2010;Opitz et al, 2014;Mahon et al, 2019) and has been used widely in identifying regions important for language, somatosensory and motor functions (Ojemann, 1983;Ostrowsky et al, 2002;Matsumoto et al, 2007;Orena et al, 2019). Moreover, cortico-cortical evoked potentials (CCEPs) induced in regions distant from the DES site has gained importance as a tool to map the spatio-temporal causal connectivity of the brain (Mandonnet et al, 2010;Keller et al, 2014).…”

Section: Direct Electrical Stimulationmentioning

confidence: 99%

Brain modeling for control: A review

Acharya

Ruf

Nozari

2022

Front. Control Eng.

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Neurostimulation technologies have seen a recent surge in interest from the neuroscience and controls communities alike due to their proven potential to treat conditions such as epilepsy, Parkinson’s Disease, and depression. The provided stimulation can be of different types, such as electric, magnetic, and optogenetic, and is generally applied to a specific region of the brain in order to drive the local and/or global neural dynamics to a desired state of (in)activity. For most neurostimulation techniques, however, an underlying theoretical understanding of their efficacy is still lacking. From a control-theoretic perspective, it is important to understand how each stimulus modality interacts with the inherent complex network dynamics of the brain in order to assess the controllability of the system and develop neurophysiologically relevant computational models that can be used to design the stimulation profile systematically and in closed loop. In this paper, we review the computational modeling studies of 1) deep brain stimulation, 2) transcranial magnetic stimulation, 3) direct current stimulation, 4) transcranial electrical stimulation, and 5) optogenetics as five of the most popular and commonly used neurostimulation technologies in research and clinical settings. For each technology, we split the reviewed studies into 1) theory-driven biophysical models capturing the low-level physics of the interactions between the stimulation source and neuronal tissue, 2) data-driven stimulus-response models which capture the end-to-end effects of stimulation on various biomarkers of interest, and 3) data-driven dynamical system models that extract the precise dynamics of the brain’s response to neurostimulation from neural data. While our focus is particularly on the latter category due to their greater utility in control design, we review key works in the former two categories as the basis and context in which dynamical system models have been and will be developed. In all cases, we highlight the strength and weaknesses of the reviewed works and conclude the review with discussions on outstanding challenges and critical avenues for future work.

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“…These methodological limitations, lack of standardization, and often lack of agreement on what is tested and how, even when testing structures we have been electrically stimulating for many decades, should be considered when wider cognitive functions beyond language are interrogated. Fortunately, a wealth of initial DES data is emerging from high-quality cognitive studies [22,27,32]. Recent reports accrue data on specific testing of wider cognitive domains including cognitive aspects of movement, such as awareness of voluntary actions using the hand manipulation task; interference control or achieving a goal through conflicting incoming information using the Stroop test; and face-based mentalising or mental state recognition using the "reading the mind in the eyes" test [3,11,29,39].…”

Section: Mapping Cognitionmentioning

confidence: 99%

Extended testing for cognition: has awake brain mapping moved to the next level?

Samandouras

2021

Acta Neurochir

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Direct electrical stimulation mapping of cognitive functions in the human brain

Cited by 11 publications

References 54 publications

Awake Craniotomy in Africa: A Scoping Review of Literature and Proposed Solutions to Tackle Challenges

Awake Craniotomy in Africa: A Scoping Review of Literature and Proposed Solutions to Tackle Challenges

Brain modeling for control: A review

Extended testing for cognition: has awake brain mapping moved to the next level?

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