Direct effects of neuropeptide nesfatin-1 on testicular spermatogenesis and steroidogenesis of the adult mice

Ranjan, Amit; Choubey, Mayank; Yada, Toshihiko; Krishna, Amitabh

doi:10.1016/j.ygcen.2018.10.022

Cited by 31 publications

(16 citation statements)

References 40 publications

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“…78 Similarly, the stimulatory effects of nesfatin-1 on spermatogenesis and steroidogenesis may be related to its antioxidant and antiapoptotic activities. 79 Further, it ameliorates the type-2 diabetes mellitus (T2DM)-associated testicular dysfunction and decreases the production of antioxidative enzymes in mice with T2DM. 80 In addition, nesfatin-1 is also expressed in the reproductive organs of female mice and has been reported to be indispensable for the onset of normal puberty in female rats.…”

Section: Other Diseasesmentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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Section: Other Diseasesmentioning

confidence: 99%

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Xu¹,

Chen²

2020

JIR

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“…Nesfatin-1 is hypothalamic 82-amino acid neuropeptide and synthesized from the apical areas of the seminiferous tubules, sertoli cells and spermatocytes in the testicle, as well as from the ovaries (8,23). It has been determined that nesfatin plays a positive role in the regulation of the reproductive system in male rats (24).…”

Section: Discussionmentioning

confidence: 99%

Effects of Carnosic and Gallic Acid on Ram Sperm Parameters and Seminal Plasma Homocysteine-Nesfatin Levels after Thawing

Öztürk

Güngör

Aksoy

et al. 2020

Dicle Üniversitesi Veteriner Fakültesi Dergisi

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In the presented study, the protective role of carnosic and gallic acid on post-thaw ram sperm acrosome and membrane integrity was examined, homocysteine (Hcy) and nesfatin levels were determined. In study semen samples from 6 Merino rams were used. Each ejaculate, split into five equal aliquots was diluted with extenders including 0.05 mM gallic acid (GA), 2 mM gallic acid, 0.05 mM carnosic acid (CA), 0.2 mM carnosic acid and no additive (control) at 37 °C cooled to 5 °C then frozen at nitrogen vapor. Freeze-thawed ram semen viability was achieved in gallic acid 2mM (57.13± 2.38%) group and statistical difference was found with control group (45.08±2.98%) (p<0.05). There was no statistical difference between the groups in HOS test analysis (p>0.05). The lowest level of homocysteine was obtained in the gallic acid groups (0.67±0.11 and 0.61±0.26 μmol/L) and was found statistically different with the control group (1.36±0.9 μmol/L) (p<0.05). No significant difference was found in nesfatin levels among groups (p>0.05). GA supplementation in ram semen extender has been determined to protect viability and HOS test parameters also to decrease homocysteine level.

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“…In line with this, it was further shown that nesfatin-1 suppresses peripheral artery remodeling likely by increasing NO production and LKB1-mediated activation of AMPK in vascular endothelial cells in mice (54). However, in the testis of mice nesfatin-1-induces an increase in G protein-coupled receptor 54 (GPR-54) accompanied by increases in PCNA, Bcl2, androgen receptor (AR), GLUT8, insulin receptor and gonadotropin-releasing hormone receptor (GnRH-R) (64,65). In addition, a potential role of protein kinase B (AKT) as a signaling mechanism for nesfatin-1induced glucose uptake and activation of the AMP-activated protein kinase (AMPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) system was found through which nesfatin-1 enhances insulin sensitivity in the testis of mice (64,66).…”

Section: Ampk Signaling Pathwaymentioning

confidence: 99%

“…However, in the testis of mice nesfatin-1-induces an increase in G protein-coupled receptor 54 (GPR-54) accompanied by increases in PCNA, Bcl2, androgen receptor (AR), GLUT8, insulin receptor and gonadotropin-releasing hormone receptor (GnRH-R) (64,65). In addition, a potential role of protein kinase B (AKT) as a signaling mechanism for nesfatin-1induced glucose uptake and activation of the AMP-activated protein kinase (AMPK)/extracellular signal-regulated kinase 1/2 (ERK1/2) system was found through which nesfatin-1 enhances insulin sensitivity in the testis of mice (64,66). Supporting these findings, icv injection of nesfatin-1 increased peripheral and hepatic insulin sensitivity by decreasing gluconeogenesis and promoting peripheral glucose uptake through the AMPK/AKT/TORC2 pathway (78).…”

Section: Ampk Signaling Pathwaymentioning

confidence: 99%

Nesfatin-1 Receptor: Distribution, Signaling and Increasing Evidence for a G Protein-Coupled Receptor – A Systematic Review

Rupp¹,

Wölk

Stengel

2021

Front. Endocrinol.

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BackgroundNesfatin-1 is an 82-amino acid polypeptide, cleaved from the 396-amino acid precursor protein nucleobindin-2 (NUCB2) and discovered in 2006 in the rat hypothalamus. In contrast to the growing body of evidence for the pleiotropic effects of the peptide, the receptor mediating these effects and the exact signaling cascades remain still unknown.MethodsThis systematic review was conducted using a search in the Embase, PubMed, and Web of Science databases. The keywords “nesfatin-1” combined with “receptor”, “signaling”, “distribution”, “pathway”, g- protein coupled receptor”, and “binding” were used to identify all relevant articles reporting about potential nesfatin-1 signaling and the assumed mediation via a Gi protein-coupled receptor.ResultsFinally, 1,147 articles were found, of which 1,077 were excluded in several steps of screening, 70 articles were included in this systematic review. Inclusion criteria were studies investigating nesfatin-1’s putative receptor or signaling cascade, observational preclinical and clinical studies, experimental studies, registry-based studies, cohort studies, population-based studies, and studies in English language. After screening for eligibility, the studies were assigned to the following subtopics and discussed regarding intracellular signaling of nesfatin-1 including the potential receptor mediating these effects and downstream signaling of the peptide.ConclusionThe present review sheds light on the various effects of nesfatin-1 by influencing several intracellular signaling pathways and downstream cascades, including the peptide’s influence on various hormones and their receptors. These data point towards mediation via a Gi protein-coupled receptor. Nonetheless, the identification of the nesfatin-1 receptor will enable us to better investigate the exact mediating mechanisms underlying the different effects of the peptide along with the development of agonists and antagonists.

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Direct effects of neuropeptide nesfatin-1 on testicular spermatogenesis and steroidogenesis of the adult mice

Cited by 31 publications

References 40 publications

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

Effects of Carnosic and Gallic Acid on Ram Sperm Parameters and Seminal Plasma Homocysteine-Nesfatin Levels after Thawing

Nesfatin-1 Receptor: Distribution, Signaling and Increasing Evidence for a G Protein-Coupled Receptor – A Systematic Review

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