Direct effects of ethanol on bone resorption and formation in vitro

Farley, John R.; Fitzsimmons, Robert J.; Taylor, A.; Jorch, U. M.; Lau, K.-H. William

doi:10.1016/0003-9861(85)90169-9

Cited by 122 publications

(49 citation statements)

References 20 publications

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“…The results from the present study demonstrate that chronic ethanol ingestion increases osteoclastogenesis and bone loss through IL-6 in mice. These findings are consistent with the observation that ethanol induces bone resorption in chick tibiae (8) and rat trabecular bone (9). Furthermore, these findings are in line with the evidence that IL-6 mediates osteoclastogenesis and bone loss in estrogen-and androgen-deficient states (30,35).…”

Section: Discussionsupporting

confidence: 91%

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Dai¹,

Lin²,

Zhang³

et al. 2000

J. Clin. Invest.

136

100

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Section: Discussionsupporting

confidence: 91%

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Dai¹,

Lin²,

Zhang³

et al. 2000

J. Clin. Invest.

136

100

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“…The effects of alcohol on the increase of bone resorption and inhibition of bone formation have been observed in histologic studies (2)(3)(4) and an vitro studies (5,6).…”

mentioning

confidence: 99%

Effect of Long-Term Alcohol Administration on Bone Metabolism in Rats.

Yamamoto

Sekino

Tajima

et al. 1997

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryThe purpose of this study was to investigate the effects of different degrees of alcohol ingestion on bone strength and mineral density. Three different groups of growing female rats were administered different doses of an alcohol-water solution for a period of 6 months. These three groups were divided into: 1) the control group, which was only given water; 2) the moderate group, which was given 5% ethanol solution for only 2 h per day; and 3) the excess group, which was given only 5% ethanol solution for 163 days. This ethanol consumption induced no detrimental effect on biochemical parameters including liver function. The moderate group showed significantly higher (p<0.05) levels of proximal metaphysis as compared to the control group, while there was no difference between the excess group and the control group. Similarly, in comparison to the control group, the moderate group ex hibited a significant increase (p<0.001) in bone mechanical strength, while the excess group showed either the same or decreased bone stiffness. These results indicate that alcohol intake has both beneficial and hinder ing effects on the skeleton, depending on the concentration and frequency of ethanol intake.

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“…Most animal studies have shown that alcohol exposure does increase markers of bone resorption both in vitro (Cheung et al, 1995;Farley et al, 1985) and in vivo (Zhang et al, 2002). Early studies of the effect of alcohol on bone remodeling found direct effects on both formation and resorption in an embryonic chick tibia in vitro model system (Farley et al, 1985), and suggested alcohol-induced alterations in bone cell membrane fluidity as a potential contributory mechanism.…”

mentioning

confidence: 99%

“…Early studies of the effect of alcohol on bone remodeling found direct effects on both formation and resorption in an embryonic chick tibia in vitro model system (Farley et al, 1985), and suggested alcohol-induced alterations in bone cell membrane fluidity as a potential contributory mechanism. More recent reports using in vitro resorption assays found primary cultured osteoclasts exposed to different concentrations of alcohol exhibited greater in vitro resorption activity than control cultures (Cheung et al, 1995).…”

mentioning

confidence: 99%

The Effects of Binge Alcohol Exposure on Bone Resorption and Biomechanical and Structural Properties are Offset by Concurrent Bisphosphonate Treatment

Callaci

Juknelis

Patwardhan

et al. 2004

Alcoholism Clin & Exp Res

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Background-Chronic alcohol consumption reduces bone mass and strength, increasing fracture risk for alcohol abusers. Mechanisms underlying this vulnerability involve modulation of bone remodeling. Direct effects of alcohol on bone formation have been documented; those on bone resorption are less well studied. Skeletal effects of exposure to high blood alcohol concentrations (BAC's) attained during binge drinking have not been studied. We examined the effects of repeated binge-like alcohol treatment on bone resorption, bone mineral density and vertebral compressive strength in adult male rats treated with the aminobisphosphonate, risedronate.

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Direct effects of ethanol on bone resorption and formation in vitro

Cited by 122 publications

References 20 publications

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Chronic alcohol ingestion induces osteoclastogenesis and bone loss through IL-6 in mice

Effect of Long-Term Alcohol Administration on Bone Metabolism in Rats.

The Effects of Binge Alcohol Exposure on Bone Resorption and Biomechanical and Structural Properties are Offset by Concurrent Bisphosphonate Treatment

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