2020
DOI: 10.1111/jnc.15034
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Direct dopamine terminal regulation by local striatal microcircuitry

Abstract: Regulation of axonal dopamine release by local microcircuitry is at the hub of several biological processes that govern the timing and magnitude of signaling events in reward-related brain regions. An important characteristic of dopamine release from axon terminals in the striatum is that it is rapidly modulated by local regulatory mechanisms. These processes can occur via homosynaptic mechanisms-such How to cite this article: NolanSO, Zachry JF, Johnson AR,

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Cited by 52 publications
(48 citation statements)
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References 237 publications
(341 reference statements)
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“…Inhibition of striatal LTSIs via overexpression of Kir2.1, an inwardly rectifying potassium channel, significantly augmented extracellular dopamine evoked by a low dose of amphetamine (Supplemental Figure 1). While this evidence supports an interaction between LTSIs and dopaminergic transmission, multiple potential mechanisms could generate these effects: (1) direct dopamine axon inhibition, (2) disinhibition of local cholinergic interneurons (ChINs), which strongly regulate dopamine 7,11 , and/or (3) disinhibition of local spiny projection neurons (SPNs), which can regulate dopamine via recurrent circuitry 12 .…”
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confidence: 95%
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“…Inhibition of striatal LTSIs via overexpression of Kir2.1, an inwardly rectifying potassium channel, significantly augmented extracellular dopamine evoked by a low dose of amphetamine (Supplemental Figure 1). While this evidence supports an interaction between LTSIs and dopaminergic transmission, multiple potential mechanisms could generate these effects: (1) direct dopamine axon inhibition, (2) disinhibition of local cholinergic interneurons (ChINs), which strongly regulate dopamine 7,11 , and/or (3) disinhibition of local spiny projection neurons (SPNs), which can regulate dopamine via recurrent circuitry 12 .…”
mentioning
confidence: 95%
“…This functional diversity is supported by an array of regulatory mechanisms to control dopamine signals across multiple temporal and spatial regimes. Importantly, local microcircuitry gates dopamine at the terminals, regulating the magnitude, spread, timing, and duration of dopamine signals 7 . A range of local homosynaptic and heterosynaptic mechanisms directly regulate dopamine at striatal terminals 7 , including striatal GABA tone [8][9][10] .…”
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confidence: 99%
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“…Terminal dopamine release in the striatum does not always correspond with action potentials from ventral tegmental and substantia nigra projection neurons (Trulson, 1985;Mohebi et al, 2019). Release is also regulated by local circuitry, by both homosynaptic and heterosynaptic mechanisms (see Nolan et al, 2020). Functionality of dopamine transporters and release probability (homosynaptic regulation) can both mediate stimulated dopamine release (see Ferris et al, 2013).…”
Section: Introductionmentioning
confidence: 99%
“…Heterosynaptic mechanisms include neurotransmitter release from local interneurons and projection neurons, such as acetylcholine interneurons, which play a major role in regulating local terminal dopamine release (see Cachope and Cheer, 2014;Collins and Saunders, 2020;Nolan et al, 2020). For example, optogenetic stimulation of acetylcholine release drives terminal dopamine release independent of action potential through activation of nicotinic acetylcholine receptors (nAChRs) on dopamine terminals (Threlfell et al, 2012;Cachope et al, 2012).…”
Section: Introductionmentioning
confidence: 99%