Direct Determination of Organic Compounds in Water at Parts-per-Quadrillion Levels by Membrane Introduction Mass Spectrometry

Soni, Manish; Bauer, Stephen M.; Amy, J. W.; Wong, Philip; Cooks, R. Graham

doi:10.1021/ac00104a016

Cited by 83 publications

(55 citation statements)

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“…SWIFT and FNF waveforms applied during ion injection into the trap have been demonstrated to remove interference and can supplement sample preparation and chromatography. 13,[49][50][51] In an attempt to eliminate this problem, operation of the rf ion guide in a high-pass mass filtering mode was evaluated and compared with the FNF technique. Most interferences from solvent background and many coeluting interferences are of lower m/z than the target compound, thus operation of the ion guide as a high-pass mass filter should be sufficient.…”

Section: High-pass Mass Filtering Using An Rf Ion Guidementioning

confidence: 99%

Investigating the use of an octupole ion guide for ion storage and high-pass mass filtering to improve the quantitative performance of electrospray ion trap mass spectrometry

Voyksner

Lee

1999

Rapid Commun. Mass Spectrom.

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An octupole radio frequency (rf) ion guide was evaluated for storage and filtering of ions generated by electrospray prior to introduction into an ion trap mass spectrometer. The control of the rf potential on the ion guide enabled its operation as a high-pass mass filter, removing low-mass chemical noise that would normally fill the ion trap and result in reduced sensitivity, mass resolution, and dynamic range. Also, the ion guide can serve to store the high-pass filtered ions during the ion trap mass analysis, enabling nearly 100% duty cycle and reduction of the cycle time by a factor of two. The linearity, precision, and detection limits of the liquid chromatography (LC) electrospray - ion guide-ion trap MS/MS system were evaluated for the determination of ceftiofur in milk. A linear calibration (linear correlation coefficient of 0.986) from 2-200 ppb was obtained with a relative standard deviation for replicate analysis of less than 8%. A quantitation detection limit of 100 pg of ceftiofur on-column (2 ppb) was achieved from a milk extract. This detection limit is nearly a factor of 10 lower compared with the determination on the same electrospray ion trap system not using a rf ion guide for high-pass mass filtering and ion storage.

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Section: High-pass Mass Filtering Using An Rf Ion Guidementioning

confidence: 99%

Investigating the use of an octupole ion guide for ion storage and high-pass mass filtering to improve the quantitative performance of electrospray ion trap mass spectrometry

Voyksner

Lee

1999

Rapid Commun. Mass Spectrom.

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“…Because these compounds are present in trace concentrations in the biosphere, low detection limits are required. Detection limits for VOCs in water have been demonstrated to be as low as parts-per-quadrillion (femtograms per gram), [5] and it is quite possible that similar results can be achieved for the metal alkyls. If adequate detection limits cannot be demonstrated for direct analysis techniques, or if the matrix precludes direct analysis, simple sample preparation steps such as on-line complexation or derivatization reactions to increase volatility or to increase the new metal-containing compound's solubility or diffusivity in the membrane, can be implemented.…”

Section: Technical Description Of Workmentioning

confidence: 96%

“…Most strikingly, detection limits for VOCs are in the low parts-per-trillion range. In fact, in favorable cases, the detection of parts-per-quadrillion levels of VOCs in water [5] and the detection of 20 parts-per-trillion by volume in air [6] have been demonstrated. Because the nonporous silicone membrane excludes particulates and ionic compounds, including the salts found in seawater, the technique offers a way to measure trace levels of organics in a complex aqueous matrix.…”

Section: Technical Description Of Workmentioning

confidence: 99%

Real-Time Broad Spectrum Characterization of Waste by Membrane Introduction Mass Spectrometry

Wilkerson¹,

Cisper²

1999

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“…The ability to selectively store ions is expected to provide a substantial improvement in limits of detection. This and related selective ion storage techniques have been used in ultra-trace-level analysis of volatile organic compounds at levels as low as parts-per-quadrillion (pg/L) (19).…”

Section: Ion Population Control By Selective Ion Manipulation Techniquesmentioning

confidence: 99%

Metabolism of Fluazifop-P-butyl in Resistant Goosegrass (Eleusine indica) in Taiwan

et al. 2017

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Mass spectrometry, the science and technology of gaseous ions (1), has as its basis the measurement of mass-to-charge ratios (m/z) of ions. All atomic and molecular ions are, in principle, accessible by mass spectrometry, making it a universal method for chemical analysis. Its implementation requires suitable methods of ion generation, ion analysis, and ion detection. We treat each of these processes in turn and show below that there are multiple methods of accomplishing each.The first step in recording a mass spectrum is to convert analyte molecules (or atoms) into gas phase ions. In biological applications, the most common ionization techniques are electrospray ionization (ES) (2), atmospheric pressure chemical ionization (APCI) (3,4), and matrix-assisted laser desorption ionization (MALDI) (5). These are soft ionization methods in the sense that at least some analyte molecules are converted, intact, into corresponding ions. Solution phase samples are examined with ES and APCI while MALDI is particularly appropriate for solid phase samples. Having successfully generated gas phase ions, they must then be mass analyzed. There are several different types of mass analyzers, all based on the interactions of charged particles with electric and/ or magnetic fields. T1 summarizes the most common mass analyzers and lists some analytical performance characteristics by which they can be compared (6). As with the various ionization methods, there is no single right choice -the nature of the problem and the resources of the laboratory will dictate which mass analyzer is most appropriate.Most uses of mass spectrometry are made in combination with chromatographic separation, principally in the form of the GC/MS or LC/MS technique. These combinations have been used, for example, in organic analysis in the environmental sciences and in characterization of biological compounds, including molecular weight (MW) determinations, and sequence analyses of biopolymers (7). Increasingly important applications have been found in drug metabolism and protein sequencing due to the high sensitivity and chemical specificity of mass spectrometry. These advantages apply even when the samples are presented to the mass spectrometer as mixtures since the two-stage tandem mass spectrometry (MS/MS) experiment serves as a method of separation as well as characterization of the separated components. Quadrupoles and Ion TrapsWith the above background on ionization and mass analysis, we can now introduce a family of mass analyzers whose operation is based on ion motion in rf electric fields. The quadrupole mass filter (8), or linear quadrupole, consists of a linear array of four symmetrically arranged rods (F1) to which rf and dc voltages are supplied. Forces are exerted in a plane normal to the direction (z-direction) in which the ions drift through the array in their journey from the ion source to the detector. The rf potential gives rise to a field which alternatively reinforces and then dominates the dc field, also applied by coupling opposite sets...

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Direct Determination of Organic Compounds in Water at Parts-per-Quadrillion Levels by Membrane Introduction Mass Spectrometry

Cited by 83 publications

References 0 publications

Investigating the use of an octupole ion guide for ion storage and high-pass mass filtering to improve the quantitative performance of electrospray ion trap mass spectrometry

Investigating the use of an octupole ion guide for ion storage and high-pass mass filtering to improve the quantitative performance of electrospray ion trap mass spectrometry

Real-Time Broad Spectrum Characterization of Waste by Membrane Introduction Mass Spectrometry

Metabolism of Fluazifop-P-butyl in Resistant Goosegrass (Eleusine indica) in Taiwan

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