Direct Determination of Cadmium, Nickel, and Zinc in Rat Lungs

Kaplan, Phyllis D.; Blackstone, M.

doi:10.1080/00039896.1973.10666409

Cited by 12 publications

(1 citation statement)

References 5 publications

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“…Tetramethylammonium hydroxide (TMAH) has been used as a 'tissue solubilizer' for various biological samples prior to analysis for major and minor inorganic elements by flame, [18][19][20][21] furnace atomic absorption spectrometry, [21][22][23][24][25] and inductively coupled plasma (ICP) atomic emission spectrometry, 26,27 and recently electrothermal vaporization ICP-mass spectrometry. 28 This alkaline digestion with TMAH offers a rapid and simple approach to the preparation of a homogenized sample solution, which is a distinct advantage over conventional slurry preparation methods.…”

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confidence: 99%

Determination of total mercury in biological tissues by flow injection cold vapour generation atomic absorption spectrometry following tetramethylammonium hydroxide digestion

Tao¹,

Willie²

1998

Analyst

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A simple, rapid and reliable method was developed for the determination of total mercury in biological samples. Samples were solubilized using tetramethylammonium hydroxide (TMAH). The organically bound mercury was cleaved and converted to inorganic mercury by on-line addition of KMnO4. The decomposed mercury together with inorganic mercury originally present in samples was determined by flow injection cold vapour atomic absorption spectrometry after reduction to elemental mercury vapour using NaBH4. A sample throughput of 100 measurements per hour was achieved after a 30 min dissolution with TMAH. The relative standard deviation for 20 micrograms l-1 Hg was 1.3% (n = 11) and the limit of detection was 0.1 microgram l-1 (3 sigma). The proposed method was validated by the analysis of a suite of certified marine biological reference materials, DORM-2 (dogfish muscle), DOLT-2 (dogfish liver) and TORT-2 (lobster hepatopancreas), with calibration against simple HgII standards.

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