Direct determination of arsenic in blood serum by electrothermal atomic absorption spectrometry

Pégon, Y.

doi:10.1016/s0003-2670(00)82602-1

Cited by 10 publications

(4 citation statements)

References 13 publications

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“…Serum Iron, (Fe) was determined according to [ 12 ]. Serum Total Iron Binding Capacity, (TIBC) [ 13 ]. Serum Transferrin saturation percent, (%TS) = (Serum Iron/TIBCx100), [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Serum heavy metals and hemoglobin related compounds in Saudi Arabia firefighters

Al-Malki

2009

J Occup Med Toxicol

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BackgroundFirefighters are frequently exposed to significant concentrations of hazardous materials including heavy metals, aldehydes, hydrogen chloride, dichlorofluoromethane and some particulates. Many of these materials have been implicated in the triggering of several diseases. The aim of the present study is to investigate the effect of fire smoke exposure on serum heavy metals and possible affection on iron functions compounds (total iron binding capacity, transferrin saturation percent, ferritin, unsaturated iron-binding capacity blood hemoglobin and carboxyhemoglobin,).Subjects and methodsTwo groups of male firefighter volunteers were included; the first included 28 firefighters from Jeddah city, while the second included 21 firefighters from Yanbu city with an overall age rang of 20–48 years. An additional group of 23 male non-firefighters volunteered from both cities as normal control subjects. Blood samples were collected from all volunteer subjects and investigated for relevant parameters.ResultsThe results obtained showed that there were no statistically significant changes in the levels of serum heavy metals in firefighters as compared to normal control subjects. Blood carboxyhemoglobin and serum ferritin were statistically increased in Jeddah firefighters, (p < 0.05 and p < 0.05 respectively) and Yanbu firefighters, (p < 0.005 and p < 0.001 respectively) as compared to normal control group while serum TIBC and UIBC were statistically decreased in Yanbu firefighters as compared to Jeddah firefighters, (p < 0.005 and p < 0.005 respectively) and normal control group, (p < 0.005 and p < 0.01 respectively). On the other hand, serum transferrin saturation percent was elevated in only Yanbu firefighters, (p < 0.05) as compared to Jeddah firefighters. Besides, there was no statistically significant change in blood hemoglobin and serum iron on comparison between all studied groups.ConclusionSuch results might point to the need for more health protective and prophylactic measures to avoid such hazardous health effects (elevated Blood carboxyhemoglobin and serum ferritin and decreased serum TIBC and UIBC) that might endanger firefighters working under dangerous conditions. Firefighters must be under regular medical follow-up through standard timetabled medical laboratory investigations to allow for early detection of any serum biochemical or blood hematological changes.

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“…Serum Iron, (Fe) was determined according to [ 12 ]. Serum Total Iron Binding Capacity, (TIBC) [ 13 ]. Serum Transferrin saturation percent, (%TS) = (Serum Iron/TIBCx100), [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

Serum heavy metals and hemoglobin related compounds in Saudi Arabia firefighters

Al-Malki

2009

J Occup Med Toxicol

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“…Presumably, nickel forms a thermally stable arsenide that prevents volatilization of arsenic until concomitant compounds have been removed during the thermal pretreatment step. 4 The optimal nickel concentration to be used was studied experimentally using first aqueous standards and then the biological fluids mentioned. It was verified that, by using 0.5% w/v nickel, the pyrolysis temperature could be raised up to 1600 °C.…”

Section: Resultsmentioning

confidence: 99%

“…In any case, matrix modification is necessary to allow increased pyrolysis temperatures, and thus to decrease the non-specific absorption signals originating from the matrix. Nickel salts [4][5][6] have been widely used as matrix modifiers for arsenic determination, although other chemicals have also been suggested for the same purpose. [7][8][9][10][11] In addition, the presence of iron and phosphate in biological matrices causes deuterium arc background correction systems to overcompensate at arsenic resonance lines such as 193.7 and 197.2 nm and so Zeeman-based background correction is commonly recommended.…”

Section: Introductionmentioning

confidence: 99%

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Determination of arsenic in biological fluids by electrothermal atomic absorption spectrometry

Campillo

Viñas

López-Garcı́a

et al. 2000

Analyst

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A procedure for the determination of the total content of arsenic in urine, serum and blood by electrothermal atomic absorption spectrometry (ETAAS) is described. Zeeman correction is used to compensate the high background signals. The samples are diluted (1 + 1 for urine and 1 + 3 for both serum and blood samples) in a medium containing 0.1% w/v Triton X-100 before being introduced directly into the furnace. A solution containing 15% w/v hydrogen peroxide, 0.65% w/v nitric acid and 0.5% w/v nickel is also introduced into the atomizer by means of a separate injection. Calibration is carried out against aqueous standards for blood and serum samples and using the standard additions method for urine samples. The detection limit is 20 pg (2 ng ml-1). The reliability of the procedure is checked by analyzing three certified reference materials and by recovery studies.

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Radiotracer study of the behaviour of arsenic in the graphite furnace

Kriváň

Arpadjan

1989

Z. Anal. Chem.

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Direct determination of arsenic in blood serum by electrothermal atomic absorption spectrometry

Cited by 10 publications

References 13 publications

Serum heavy metals and hemoglobin related compounds in Saudi Arabia firefighters

Serum heavy metals and hemoglobin related compounds in Saudi Arabia firefighters

Determination of arsenic in biological fluids by electrothermal atomic absorption spectrometry

Radiotracer study of the behaviour of arsenic in the graphite furnace

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