Direct Conversion of Fibroblast into Neurons for Alzheimer’s Disease Research: A Systematic Review
Roman Sattarov,
Håkan Toresson,
Camilla Orbjörn
et al.
Abstract:Background: Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder without a cure. Innovative disease models, such as induced neurons (iNs), could enhance our understanding of AD mechanisms and accelerate treatment development. However, a review of AD human iN studies is necessary to consolidate knowledge. Objective: The objective of this review is to examine the current body of literature on AD human iN cells and provide an overview of the findings to date. Methods: We searched two databases for r… Show more
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