Direct compression properties of chitin and chitosan

Mir, Viviana García; Heinämäki, Jyrki; Antikainen, Osmo; Revoredo, Ofelia Bilbao; Colarte, Antonio Iraizoz; Nieto, Olga María; Yliruusi, Jouko

doi:10.1016/j.ejpb.2008.01.029

Cited by 29 publications

(14 citation statements)

References 8 publications

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“…Chitosan shows good compression behavior when compared with other excipients used for direct compression [110]. However, very few examples of chitosan and chitosan derivatives matrix tablets can be founded, partially due to the low contact surface of the dosage form with the mucosal site, therefore limiting the absorption area.…”

Section: Tabletsmentioning

confidence: 98%

Chitosan Formulations as Carriers for Therapeutic Proteins

Andrade

Antunes²,

Nascimento³

et al. 2011

CDDT

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Protein drugs represent a significant part of the new pharmaceuticals coming on the market every year and are now widely spread in therapy to treat or relief symptomatology related to many metabolic and oncologic diseases. The delivery of therapeutic proteins is still a major drawback against their maximum pharmacodynamic due to their physicochemical properties, poor stability, permeability and biodistribution. Despite the fact that the parenteral route remains the primary route of protein administration, research continues on non-parenteral delivery routes. However, the high molecular weight of proteins, combined with their hydrophilic and charged nature, renders transport through membranes very difficult. In this regard, the biopolymer chitosan exhibits several favorable biological properties, such as biocompatibility, biodegradability, low-toxicity and mucoadhesiveness, which made it a promising candidate for the formulation of protein drugs. The success of a protein formulation depends not only on the stability of the delivery system but also on their ability to maintain the native structure and activity of the protein during preparation and the delivery, as well as during longterm storage of the formulation. Chitosan-based delivery systems have been proposed as valid approaches to provide such protective conditions. The development of novel protein delivery systems based on chitosan is a rising subject irrespective of the intended route of administration. In this review, the different approaches recently exploited to formulate and deliver therapeutic proteins are underlined.

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Section: Tabletsmentioning

confidence: 98%

Chitosan Formulations as Carriers for Therapeutic Proteins

Andrade

Antunes²,

Nascimento³

et al. 2011

CDDT

View full text Add to dashboard Cite

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“…Chitin is an excellent support material for enzyme immobilization because of its various characteristics including hydrophilicity, biocompatibility, biodegradability and physiochemical stability. Moreover, this biopolymer is susceptible to chemical modification due to the amine and hydroxyl groups that facilitate the covalent binding with the enzyme [8,11]. Fig.…”

Section: Chemically Crosslinked Chitin and Peroxidase Immobilizationmentioning

confidence: 99%

Development of biosensor based on ionic liquid and corn peroxidase immobilized on chemically crosslinked chitin

Brondani

Dupont

Spinelli

et al. 2009

Sensors and Actuators B: Chemical

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“…Chitin and chitosan prepared from lobster were studied on their deformation and compaction properties for use as pharmaceutical direct compression excipients (Mir et al 2008). In comparison with other established direct compression excipients (microcrystalline cellulose), lobster chitin/chitosan performed better at both tendencies of plastic deformation and compression behavior.…”

Section: Various Applications Of Extracts Derived From Lpbsmentioning

confidence: 99%

Lobster processing by-products as valuable bioresource of marine functional ingredients, nutraceuticals, and pharmaceuticals

Nguyễn

Barber

Corbin

et al. 2017

Bioresour. Bioprocess.

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The worldwide annual production of lobster was 165,367 tons valued over $3.32 billion in 2004, but this figure rose up to 304,000 tons in 2012. Over half the volume of the worldwide lobster production has been processed to meet the rising global demand in diversified lobster products. Lobster processing generates a large amount of by-products (heads, shells, livers, and eggs) which account for 50–70% of the starting material. Continued production of these lobster processing by-products (LPBs) without corresponding process development for efficient utilization has led to disposal issues associated with costs and pollutions. This review presents the promising opportunities to maximize the utilization of LPBs by economic recovery of their valuable components to produce high value-added products. More than 50,000 tons of LPBs are globally generated, which costs lobster processing companies upward of about $7.5 million/year for disposal. This not only presents financial and environmental burdens to the lobster processors but also wastes a valuable bioresource. LPBs are rich in a range of high-value compounds such as proteins, chitin, lipids, minerals, and pigments. Extracts recovered from LPBs have been demonstrated to possess several functionalities and bioactivities, which are useful for numerous applications in water treatment, agriculture, food, nutraceutical, pharmaceutical products, and biomedicine. Although LPBs have been studied for recovery of valuable components, utilization of these materials for the large-scale production is still very limited. Extraction of lobster components using microwave, ultrasonic, and supercritical fluid extraction were found to be promising techniques that could be used for large-scale production. LPBs are rich in high-value compounds that are currently being underutilized. These compounds can be extracted for being used as functional ingredients, nutraceuticals, and pharmaceuticals in a wide range of commercial applications. The efficient utilization of LPBs would not only generate significant economic benefits but also reduce the problems of waste management associated with the lobster industry. This comprehensive review highlights the availability of the global LPBs, the key components in LPBs and their current applications, the limitations to the extraction techniques used, and the suggested emerging techniques which may be promising on an industrial scale for the maximized utilization of LPBs. Graphical abstractLobster processing by-product as bioresource of several functional and bioactive compounds used in various value-added products

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Direct compression properties of chitin and chitosan

Cited by 29 publications

References 8 publications

Chitosan Formulations as Carriers for Therapeutic Proteins

Chitosan Formulations as Carriers for Therapeutic Proteins

Development of biosensor based on ionic liquid and corn peroxidase immobilized on chemically crosslinked chitin

Lobster processing by-products as valuable bioresource of marine functional ingredients, nutraceuticals, and pharmaceuticals

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