Direct Compression Behavior of Low- and High-Methoxylated Pectins

Abstract

The objective of this study was to evaluate possible usefulness of pectins for direct compression of tablets. The deformation behavior of pectin grades of different degree of methoxylation (DM), namely, 5%, 10%, 25%, 35%, 40%, 50%, and 60% were, examined in terms of yield pressures (YP) derived from Heckel profiles for both compression and decompression and measurements of elastic recovery after ejection. All pectin grades showed a high degree of elastic recovery. DM 60% exhibited most plastic deformation (YP 70.4 MPa) whereas DM 5% (104.6 MPa) and DM 10% (114.7 MPa) least. However, DM 60% gave no coherent tablets, whereas tablet tensile strengths for DM 5% and DM 10% were comparable to Starch 1500®. Also, Heckel profiles were similar to Starch 1500®. For sieved fractions (180–250 and 90–125 μm) of DM 25% and DM 40% originating from the very same batch, YPs were alike, indicating minor effects of particle size. These facts indicate that DM is important for the compaction behavior, and batch-to-batch variability should also be considered. Therefore, pectins of low degree of methoxylation may have a potential as direct compression excipients.

Main criteria of sustainable natural fibre for efficient unidirectional biocomposites

“…Finally, it is interesting to note that the density values obtained by gas pycnometer are all very similar, whatever the plants considered, they are between 1.489 ± 0.004 and 1.554 ± 0.004. This result shows that, whatever the biochemical composition of the walls, their densities are close, which confirms that the densities of their constituents are similar [46]. The use of two methods also shows the limits of certain techniques [47]; liquid immersion measurements make it possible to obtain apparent fibre densities whereas by using gas pycnometer, it is possible, depending on the morphology of the fibres, to approach the true density of the plant fibre walls.…”

Evaluation of Citrus Fibers as a Tablet Excipient

“…The calculated yield pressure value of the CFIB was 89.9 ±3.2 MPa, which is a value typical of a material that shows a predominantly plastic deformation mechanism when subjected to a compression process inside a confined space. This behavior has been observed for many other polysaccharides such as MCC (37)(38)(39)(40), several types of starch (39)(40)(41), or pectin (40).…”

Resonant soft X-ray scattering reveals cellulose microfibril spacing in plant primary cell walls

“…Onion epidermal walls from the 11 th scale have a thickness of about 1 μm, or 2000 times lower than the ideal thickness. Furthermore, the contrast between cellulose and pectin is small, because the densities of cellulose (1.599 g/cm 3 ) 54 and pectin (1.543 g/cm 3 ) 55 are similar. Thus, contrast is limited at 10 keV.…”