Direct comparison study between FDG-PET and IMP-SPECT for diagnosing Alzheimer's disease using 3D-SSP analysis in the same patients

Abstract

No significant difference was observed in the area under the ROC curve (AUC) between FDG-PET and IMP-SPECT images (FDG-PET 0.95, IMP-SPECT 0.94). However, a significant difference (P < 0.05) was observed in the AUC for the posterior cingulate gyri/precuneus (FDG-PET 0.94, IMP-SPECT 0.81). The sensitivity and specificity of each modality were 86%, and 97% for FDG-PET and 70% and 100% for IMP-SPECT. We could find no significant difference between FDG-PET and IMP-SPECT in terms of diagnosing moderate AD using 3D-SSP. There was a high correlation between the two modalities in the parietotemporal region (Spearman's r = 0.82, P < 0.001). The correlation in the posterior cingulate gyri/precunei region was lower than that in the parietotemporal region (Spearman's r = 0.63, P < 0.016).

Dual-Biomarker Imaging of Regional Cerebral Amyloid Load and Neuronal Activity in Dementia with PET and 11C-Labeled Pittsburgh Compound B

“…A limited diagnostic sensitivity was indeed observed for the diagnosis of AD with 15 O-water PET (36). Furthermore, in direct comparison to 18 F-FDG PET, the sensitivity of 123 I-IMP SPECT was somewhat lower (70% vs. 86%), albeit overall diagnostic accuracy in moderate AD did not differ (3). This underlines the need for further prospective studies to validate the diagnostic value of dual-biomarker 11 C-PIB PET studies in comparison to combined 18 F-FDG and 11 C-PIB PET studies for diagnosis and monitoring of the progression of AD.…”

“…Under physiologic conditions (at rest and during activation), they are closely coupled markers of neuronal activity (2). Furthermore, a comparison of both biomarkers in AD suggests that AD-induced changes in CBF and glucose metabolism are also tightly coupled (3). Another biomarker of AD, which has gained tremendous attention and acceptance in recent years, is cerebral amyloid-b (Ab) peptide deposition imaged with PET.…”

A Comparison of the Diagnostic Sensitivity of MRI, CBF-SPECT, FDG-PET and Cerebrospinal Fluid Biomarkers for Detecting Alzheimer’s Disease in a Memory Clinic

“…Although there are a few studies that directly compared CBF-SPECT and FDG-PET for the diagnosis of AD, FDG-PET was reported to have an identical or superior diagnostic value compared to N -isopropyl-p-123 I iodoamphetamine CBF-SPECT [31] . In our study, FDG-PET gave positive results with a high percentage at CDR 1 or 2; however, CBF-SPECT with 99m Tc-ECD did not achieve such a high positive rate.…”

Is there Still a Place for Perfusion SPECT in the Diagnosis of Dementia?

“…Ishii and colleagues compared F-18-FDG-PET with IMP-SPECT in patients with DLB; reductions of tracer uptake were found in posterior parietal and to a lesser extent in occipital cortex, with PET appearing to be more sensitive to abnormalities [86]. Clinical utility in predicting outcome appears greater for FDG-PET than for SPECT [87,88], although opinions about their respective merits differ [1][2][3].…”

“…Opinions differ about the relative advantages of PET and SPECT in the diagnosis of the dementias [1][2][3][4]. Of the industrialised countries, particularly Europe and Japan still use SPECT frequently for diagnostic purposes in dementia [5], in general the US literature tends to ignore clinical SPECT and expects FDG-PET to be available.…”