Direct Comparison of Single-Scan Autoradiographic with Multiple-Scan Least-Squares Fitting Approaches to PET CMRO<sub>2</sub> Estimation

Holden, James E.; Eriksson, Lars; Roland, Per E.; Stone‐Elander, Sharon; Widén, L.; Kesselberg, M.

doi:10.1038/jcbfm.1988.114

Cited by 14 publications

(10 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the above observations, the use of a separately measured value of H2150 clearance (or CBF) may introduce an error into the calculation of oxygen consumption by the three-step method. In addition, the separately measured clearance may not remain representative during the 30 to 40 minutes required to measure oxygen consumption (Meyer et al, 1987;Correia et al, 1985;Holden et al, 1988;Lam mertsma et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

“…Meyer et al (1987) ob tained reliable estimates of oxygen consumption from a single oxygen bolus inhalation study but, on the basis of the current model, showed that simul taneous estimates of blood flow and blood volume were unreliable. Holden et al (1988) stressed that accurate knowledge of the partition volume of wa ter is essential for the estimation of oxygen con sumption from a single oxygen study with the cur rent model. Lammertsma et al (1986) The new model solution overcomes some of the shortcomings mentioned above and yields oxygen consumption in a single dynamic [,50]OZ inhalation study of only 3-min duration.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oxygen Consumption of the Living Human Brain Measured after a Single Inhalation of Positron Emitting Oxygen

Ohta

Meyer

Thompson

et al. 1992

J Cereb Blood Flow Metab

126

127

View full text Add to dashboard Cite

Summary:We measured the rate of washout of 150_ labeled water generated from labeled oxygen accumu lated in brain after bolus [150]02 inhalation, and com pared the washout with that of labeled water measured with H2150. Contrary to the original expectation, the ra dioactive water generated from labeled oxygen failed to leave the brain tissue at the rate predicted by exogenous water. Therefore, the use of a separately measured value for exogenous water clearance led to an error in the cal culation of oxygen consumption. A new method pre sented in this paper eliminated the error by yielding ox ygen consumption in a single oxygen study. We used Measurements of the oxygen consumption of in dividual brain regions have been possible only after the advent of positron emission tomography (PET). Two methods have been reported, both intended to yield the unidirectional clearance of the very short lived oxygen isotope, oxygen-15. The equilibrium method (Frackowiak et aI., 1980) yielded the oxy gen clearance from the steady-state balance be tween oxygen influx, radioactive oxygen decay, and radioactive water efflux. The autoradiographic method (Mintun et aI., 1984) yielded the clearance from a transient (non-steady-state) analysis of the uptake. Both methods required separately obtained information about blood flow and blood volume and assumed, therefore, that the physiological state of the subject, and its position in the scanner, re mained unchanged for 30-60 min, the time required Abbreviation used: CBV, cerebral blood volume; CMROz, ce rebral metabolic rate for oxygen; FWHM, full width at half max imum; OEF, oxygen extraction fraction; PET, positron emission tomography; RMS, root mean squared. 179time-weighted integration to estimate three parameters, including the unidirectional clearance from blood to brain (K? 2 ), the fractional clearance of the distribution volume in brain (k�2), and the vascular volume correction (yo) ' We showed that the clearance of oxygen from blood to brain can be estimated with acceptable precision by this new approach, and that the new method yields a reliable measure of oxygen consumption. Key Words: Positron emission tomography-Oxygen consumption-U nidirec tional clearance of oxygen-Single oxygen study-Time weighted integration method.to perform three separate studies by positron emis sion tomography. In addition, both methods de pended on several simplifying assumptions which may cast doubt on the results. However, the uncer tainty is not easy to resolve because of the absence of independently obtained regional values that might serve as the ultimate standard.To examine the consequences of the specific an alytic method for the calculated oxygen consump tion values, we modified the experimental approach to yield values of oxygen consumption from a single short (3 min) bolus e50]02 inhalation study, elimi nating some assumptions but introducing others.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oxygen Consumption of the Living Human Brain Measured after a Single Inhalation of Positron Emitting Oxygen

Ohta

Meyer

Thompson

et al. 1992

J Cereb Blood Flow Metab

126

127

View full text Add to dashboard Cite

show abstract

“…There have been other attempts to obtain CBF and CMRO 2 images more rapidly (Huang et al, 1986;Holden et al, 1988;Meyer et al, 1987;Ohta et al, 1992;Ho and Feng, 1999). Mathematical refinement has allowed images to be generated from data from a single scan alone on a bolus inhalation of 15 O 2 .…”

Section: Introductionmentioning

confidence: 99%

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Kudomi

Hayashi

Teramoto

et al. 2005

J Cereb Blood Flow Metab

101

View full text Add to dashboard Cite

Cerebral blood flow (CBF) and rate of oxygen metabolism (CMRO 2 ) may be quantified using positron emission tomography (PET) with 15 O-tracers, but the conventional three-step technique requires a relatively long study period, attributed to the need for separate acquisition for each of 15 O 2 , H 2 15 O, and C 15 O tracers, which makes the multiple measurements at different physiologic conditions difficult. In this study, we present a novel, faster technique that provides a pixel-by-pixel calculation of CBF and CMRO 2 from a single PET acquisition with a sequential administration of 15 O 2 and H 2 15 O. Experiments were performed on six anesthetized monkeys to validate this technique. The global CBF, oxygen extraction fraction (OEF), and CMRO 2 obtained by the present technique at rest were not significantly different from those obtained with three-step method. The global OEF (gOEF) also agreed with that determined by simultaneous arterio-sinus blood sampling (gOEF AÀV ) for a physiologically wide range when changing the arterial PaCO 2 (gOEF ¼ 1.03gOEF AÀV þ 0.01, Po0.001). The regional values, as well as the image quality were identical between the present technique and three-step method for CBF, OEF, and CMRO 2 . In addition, a simulation study showed that error sensitivity of the present technique to delay or dispersion of the input function, and the error in the partition coefficient was equivalent to that observed for three-step method. Error sensitivity to cerebral blood volume (CBV) was also identical to that in the three-step and reasonably small, suggesting that a single CBV assessment is sufficient for repeated measures of CBF/CMRO 2 . These results show that this fast technique has an ability for accurate assessment of CBF/CMRO 2 and also allows multiple assessment at different physiologic conditions.

show abstract

“…The availability of a bolus inhalation protocol would enable more widespread use of 15 O 2 gas measurements. Such a protocol has previously been described for cerebral oxygen consumption (3,4), but its use for myocardial imaging has not been described and presents several additional challenges, mainly because of increased scatter and image noise and the presence of large amounts of radioactivity in the lungs during the bolus inhalation period. The measured radioactivity concentration in the myocardial wall is affected both by the limited spatial resolution of PET relative to the thickness of the myocardium and by spillover from the left-and right-ventricular cavities and the lungs.…”

mentioning

confidence: 99%

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of ¹⁵O-Oxygen Gas and Dynamic PET

Lubberink¹,

Wong²,

Raijmakers³

et al. 2010

J Nucl Med

View full text Add to dashboard Cite

The aim of this study was to determine the accuracy of oxygen extraction fraction (OEF) measurements using a dynamic scan protocol after bolus inhalation of 15 O 2 . The method of analysis was optimized by investigating potential reuse of myocardial blood flow (MBF), perfusable tissue fraction, and blood and lung spillover factors derived from separate 15 O-water and C 15 O scans. Methods: Simulations were performed to assess the accuracy and precision of OEF for a variety of models in which different parameters from 15 O-water and C 15 O scans were reused. Reproducibility was assessed in 8 patients who underwent one 10-min dynamic scan after bolus injection of 1.1 GBq of 15 O-water, two 10-min dynamic scans after bolus inhalation of 1.4 GBq of 15 O 2 , and a 6-min static scan after bolus inhalation of 0.8 GBq of C 15 O for region-of-interest definition. Results: Simulations showed that accuracy and precision were lowest when all parameters were determined from the 15 O 2 scan. The optimal accuracy and precision of OEF were obtained when fixing MBF, perfusable tissue fraction, and blood spillover to values derived from a 15 O-water scan and estimating spillover from the pulmonary gas volume using an attenuation map. Optimal accuracy and precision were confirmed in the patient study, showing an OEF test-retest variability of 13% for the whole myocardium. Correction of spillover from pulmonary gas volume requires correction of the lung time-activity curve for pulmonary blood volume, which could equally well be obtained from a 15 O-water rather than C 15 O scan. Conclusion: Measurement of OEF is possible using bolus inhalation of 15 O 2 and a dynamic scan protocol, with optimal accuracy and precision when other relevant parameters, such as MBF, are derived from an additional 15 O-water scan. Oxygen extraction fraction (OEF) is an important parameter in describing myocardial function (1). Oxygen delivery to the healthy myocardium is regulated by varying myocardial blood flow (MBF) in response to changes in oxygen demand. In diseased myocardium, however, this relationship may be disturbed, and measurement of myocardial oxygen consumption could provide additional information, because oxygen supply to the heart may also be moderated by changes in OEF.Measurement of regional myocardial oxygen consumption has previously been described using steady-state or autoradiographic methods and applying continuous inhalation of 15 O 2 oxygen gas (1,2). Apart from the 15 O 2 scan, this protocol requires additional 15 O-water and C 15 O scans to measure MBF and blood volume, respectively. Many current low-energy proton cyclotrons, however, cannot provide a steady-state delivery of 15 O 2 to the patient. The availability of a bolus inhalation protocol would enable more widespread use of 15 O 2 gas measurements. Such a protocol has previously been described for cerebral oxygen consumption (3,4), but its use for myocardial imaging has not been described and presents several additional challenges, mainly because of increased scatter and...

show abstract

Direct Comparison of Single-Scan Autoradiographic with Multiple-Scan Least-Squares Fitting Approaches to PET CMRO₂ Estimation

Cited by 14 publications

References 11 publications

Oxygen Consumption of the Living Human Brain Measured after a Single Inhalation of Positron Emitting Oxygen

Oxygen Consumption of the Living Human Brain Measured after a Single Inhalation of Positron Emitting Oxygen

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of ¹⁵O-Oxygen Gas and Dynamic PET

Contact Info

Product

Resources

About

Direct Comparison of Single-Scan Autoradiographic with Multiple-Scan Least-Squares Fitting Approaches to PET CMRO2 Estimation

Cited by 14 publications

References 11 publications

Oxygen Consumption of the Living Human Brain Measured after a Single Inhalation of Positron Emitting Oxygen

Oxygen Consumption of the Living Human Brain Measured after a Single Inhalation of Positron Emitting Oxygen

Rapid Quantitative Measurement of CMRO2 and CBF by Dual Administration of 15O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of 15O-Oxygen Gas and Dynamic PET

Contact Info

Product

Resources

About

Direct Comparison of Single-Scan Autoradiographic with Multiple-Scan Least-Squares Fitting Approaches to PET CMRO₂ Estimation

Rapid Quantitative Measurement of CMRO₂ and CBF by Dual Administration of ¹⁵O-Labeled Oxygen and Water During a Single PET Scan—a Validation Study and Error Analysis in Anesthetized Monkeys

Myocardial Oxygen Extraction Fraction Measured Using Bolus Inhalation of ¹⁵O-Oxygen Gas and Dynamic PET