Direct Comparison of Endothelial and Metabolic Effects of Perindopril Combination With Indapamide Retard or Hydrochlorotiazide

Loginova, E.; Zhenatov, A.B.; Живилова, Л. А.; Nechaeva, G.I. Nechaeva; Pritykina, T. V.; Чиндарева, О. И.; Stroeva, T.V. Stroeva

doi:10.18565/cardio.2014.11.25-29

Cited by 2 publications

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“…The observed beneficial effect with the perindopril/indapamide SPC may also be partially explained by the replacement of hydrochlorothiazide, which is often used for the treatment of hypertension, with indapamide. Indapamide is considered a preferred drug for obesity-related hypertension because of its marked antihypertensive effect, as well as multiple organ-protective properties [16][17][18]33].…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study

Глезер

Investigators²

2020

Cardiol Ther

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Introduction: Overweight and obesity are increasing worldwide and are associated with an increased risk for cardiovascular disease (CVD). The aim of this study was to examine the burden of CVD risk factors among normal weight, overweight, and obese subjects with hypertension, and to evaluate the effectiveness of switching to a single-pill combination (SPC) of perindopril arginine/indapamide for blood pressure (BP) control in overweight and obese subjects treated in routine clinical practice. Methods: FORSAGE was a 3-month, multicenter, observational, open-label study conducted in Russian patients with uncontrolled arterial hypertension under previous antihypertensive therapy. Subjects were switched to the full-dose Enhanced Digital Features To view enhanced digital features for this article go to https://doi.org/10.6084/ m9.figshare.11603973. For a list of study investigators see Online Supplementary Material.

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Section: Discussionmentioning

confidence: 99%

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study

Глезер

Investigators²

2020

Cardiol Ther

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“…с участием 50 пациентов с гипертонической болезнью изучали влияние антигипертензивных и метаболических эффектов тиазидных диуретиков (гидрохлоротиазида и индапамида) на функцию эндотелия сосудов и коронарный риск у пациентов с эссенциальной АГ в течение 12 нед. Эффект препаратов на эндотелий-зависимую вазодилатацию улучшался при приеме индапамида (+8,9%; р=0,10) и был значительно хуже при применении гидрохлоротиазида (-17,0%; р<0,05) [49].…”

Section: влияние на биологию теломер -возможный путь к замедлению стаunclassified

Antihypertensive therapy: controlling the processes of replicative cell senescence

et al. 2020

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The review includes data over the past 20 years on the mechanisms of the influence of hypertension and related interdependent conditions, such as insulin resistance, chronic inflammation and oxidative stress on the vascular ageing. The review also discusses modern concepts of the interaction of biological and vascular aging, as well as possible ways of their reversal. The central indicators of biological aging in this review are telomere length and telomerase activity. The article discusses antihypertensive therapy as a possible way to slow down both vascular and biological aging, and describes the results of modern studies on the effect of various antihypertensives, including angiotensin-converting enzyme inhibitors, sartans and others, on the telomeres.

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Direct Comparison of Endothelial and Metabolic Effects of Perindopril Combination With Indapamide Retard or Hydrochlorotiazide

Cited by 2 publications

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Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study

Antihypertensive therapy: controlling the processes of replicative cell senescence

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