Direct compaction: An update of materials, trouble-shooting, and application

Li, Zhe; Zhao, Lihua; Lin, Xiao; Shen, Lan; Feng, Yi

doi:10.1016/j.ijpharm.2017.07.035

Cited by 45 publications

(24 citation statements)

References 143 publications

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“…US2, the core particle of all granules, has good compactability because this particle is porous. 19,20) However, increasing the granulation time caused complete adsorption of TR-FB and the consequent loss of compactability of US2, leading to a decrease in tensile strength. In addition, any significant two-factor interactions were not observed.…”

Section: Optimization Of Manufacturing Conditions For Orallymentioning

confidence: 99%

Controlled-Release Fine Particles Prepared by Melt Adsorption for Orally Disintegrating Tablets

Shiino

Oshima

Sonoda

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

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Melt adsorption is a manufacturing method that offers precise control of particle size distribution of granules and circumvents the disadvantages of conventional melt granulation. However, drug release from particles adsorbed with hydrophobic materials has not been fully investigated, and there are missing details as to whether particles manufactured by this technique can be applied to orally disintegrating tablets (ODT). In this report, we aimed to optimize process parameters and formulation to manufacture ODT containing melt adsorption-particles with the specific characteristic of sustained release. Melt adsorption particles containing Neusilin US2 as the adsorbent were prepared by using various waxes to determine the most suitable material for controlled release formulation. Glycerol fatty acid ester (Poem TR-FB: TR-FB) was the optimal wax examined because of its drug release pattern and tabletability. We then optimized manufacturing conditions by examining granulation time, disintegrant amount per tablet and compression force on the tablet for ODT that meet the criteria of controlled drug release, tensile strength and disintegration of the tablet. Multiple regression analysis revealed the effect of process parameters on tablet properties and drug release with increasing the granulation time affording sustained release of the drug. The analysis also showed that a high compression force crushed the granules coated by TR-FB, which impaired sustained drug release. From the regression model the optimal manufacturing conditions were determined, and the tablet prepared under these conditions concurred with the predicted values and met all criteria. This new technique should contribute to the development of ODT to improve medication adherence.

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Section: Optimization Of Manufacturing Conditions For Orallymentioning

confidence: 99%

Controlled-Release Fine Particles Prepared by Melt Adsorption for Orally Disintegrating Tablets

Shiino

Oshima

Sonoda

et al. 2019

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…A stable tablet will maintain such bonds during decompression, while unstable tablets will undergo cracking and crumbling due to elastic recovery (Hiestand, 1997). Due to these prerequisite properties for direct compression, less than 20% of drug compounds are suitable candidates for this type of tablet (Li et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets

Fuenmayor

Forde

Healy

et al. 2019

International Journal of Pharmaceutics

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“…These can severely decrease the tablet quality, yield, and productivity. [4][5][6] Till now, certain strategies have been used to resolve the problem of punch sticking of ETs that occurs during compaction. Traditionally, several water-soluble lubricants (like macrogol 6000) are oen added in ETs, which can disperse on the surfaces of steel and/or effervescent granules to decrease their contact during tableting and therefore reduce the risk of sticking.…”

Section: Introductionmentioning

confidence: 99%

“…Traditionally, several water-soluble lubricants (like macrogol 6000) are oen added in ETs, which can disperse on the surfaces of steel and/or effervescent granules to decrease their contact during tableting and therefore reduce the risk of sticking. 4,7 Moreover, certain anti-adherent agents (e.g., sucrose ester) incorporated into ETs can have a benecial impact on highly adhesive granules. 3 Furthermore, in other studies, the tableting process or instruments could also inuence the extent of the sticking of ETs.…”

Section: Introductionmentioning

confidence: 99%

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

Zheng

Yang

et al. 2019

RSC Adv.

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Direct compaction: An update of materials, trouble-shooting, and application

Cited by 45 publications

References 143 publications

Controlled-Release Fine Particles Prepared by Melt Adsorption for Orally Disintegrating Tablets

Controlled-Release Fine Particles Prepared by Melt Adsorption for Orally Disintegrating Tablets

Comparison of fused-filament fabrication to direct compression and injection molding in the manufacture of oral tablets

Improvements in sticking, hygroscopicity, and compactibility of effervescent systems by fluid-bed coating

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