Direct Catalytic Stereoselective Synthesis of C4′ Functionalized Furanoside and Nucleoside Derivatives with a Tetrasubstituted Stereocenter
Kaiheng Zhang,
Haibo Wu,
A. Ken Inge
et al.
Abstract:A direct catalytic stereoselective synthesis of C4’ functionalized furanoside and nucleoside derivatives with a tetrasubstituted stereocenter is disclosed. The amine‐catalyzed stereoselective α‐aminomethylation reactions on furanoside‐derived aldehyde derivatives gave the corresponding C4’ functionalized D‐ or L‐ribose derivatives in good to excellent yields (67‐94%) with up to >20:1 dr.
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