Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase
Rebecca A. Faulkner,
Yangyan Yang,
Jet Tsien
et al.
Abstract:The maintenance of cholesterol homeostasis is crucial for normal function at both the cellular and organismal levels. Two integral membrane proteins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and Scap, are key targets of a complex feedback regulatory system that operates to ensure cholesterol homeostasis. HMGCR catalyzes the rate-limiting step in the transformation of the 2-carbon precursor acetate to 27-carbon cholesterol. Scap mediates proteolytic activation of sterol regulatory element-binding… Show more
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