Direct and Reverse Pluronic Micelles: Design and Characterization of Promising Drug Delivery Nanosystems

Naharros-Molinero, Almudena; Caballo-González, María Ángela; Mata, F. Javier de la; García‐Gallego, Sandra

doi:10.3390/pharmaceutics14122628

Cited by 32 publications

(20 citation statements)

References 121 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To analyze the required hydrophilic-lipophilic balance to generate adequate hydrogels, we synthesized a library of different polymers P(SH) 2 from different precursors: PEG 1k , PPG 1k , PLU L31 , PLU L35 and PLU L61. We adapted the protocol previously described for P1 by Macdougall et al [ 18 ]. The dithiol polymers ( P1 – P5 ) were prepared from the commercial precursors through esterification with 2-mercaptopropionic acid at 100° C in toluene.…”

Section: Resultsmentioning

confidence: 99%

“…Pluronics are a family of block copolymers (X-Y-X) formed by polyethylene glycol (PEG) and propylene glycol (PPG). These amphiphilic copolymers are highly versatile and commercially available in a broad range of molecular weights and hydrophilic–lipophilic balance (HLB) values [ 18 ]. These polymers show remarkable property changes in response to temperature, making them very promising for biomedical applications and as a possible drug delivery vehicle due to their excellent biocompatibility and environmental sensitivity [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

Muñoz-Sánchez,

Barrios-Gumiel,

de la Mata

et al. 2024

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Dendritic hydrogels based on carbosilane crosslinkers are promising drug delivery systems, as their amphiphilic nature improves the compatibility with poorly water-soluble drugs. In this work, we explored the impact of the complementary polymer on the amphiphilic properties of the dendritic network. Different polymers were selected as precursors, from the highly lipophilic propylene glycol (PPG) to the hydrophilic polyethylene glycol (PEG), including amphiphilic Pluronics L31, L35 and L61. The dithiol polymers reacted with carbosilane crosslinkers through UV-initiated thiol–ene coupling (TEC), and the resultant materials were classified as non-swelling networks (for PPG, PLUL31 and PLUL61) and high-swelling hydrogels (for PEG and PLUL35). The hydrogels exhibited thermo-responsive properties, shrinking at higher temperatures, and exhibited an intriguing drug release pattern due to internal nanostructuring. Furthermore, we fine-tuned the dendritic crosslinker, including hydroxyl and azide pendant groups in the focal point, generating functional networks that can be modified through degradable (ester) and non-degradable (triazol) bonds. Overall, this work highlighted the crucial role of the amphiphilic balance in the design of dendritic hydrogels with thermo-responsive behavior and confirmed their potential as functional networks for biomedical applications.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

Muñoz-Sánchez,

Barrios-Gumiel,

de la Mata

et al. 2024

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the introduction section we underlined the advantages of using ethanol as a co-solvent, including in experiments in micellar systems exemplified by several drug compounds [ 24 , 25 , 26 , 27 ]. In this study we measured the solubility of UMF in the presence of 10% and 20% ethanol (EtOH) in pure buffer pH 7.4 and with the additions of F-127 ( Figure 2 , Table S1 ).…”

Section: Resultsmentioning

confidence: 99%

“…Various ethanol concentrations are used in medicines: less than 2% as a solvent in the flavoring components, and at about 10% in oral liquids [ 23 ]. Systems in which both pluronic F-127 ( Figure 1 b) and ethanol were used in order to solubilize drug compounds have been reported in the literature [ 24 , 25 , 26 , 27 ]. It has been estimated that short-chain alcohols (for example, ethanol) influence the micelle formation process of block copolymers [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Revisiting the Solubility–Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent

2023

View full text Add to dashboard Cite

This study describes the influence of pluronic F-127 (F-127) and ethanol (EtOH) on the solubility of umifenovir (UMF) in buffer solutions of pH 2.0 and pH 7.4, and its permeability through cellulose membranes. A 44.4-fold greater UMF solubility in acidic medium as compared to an alkaline one was estimated at 310.15 K. The concentration of UMF in the saturated solution was enhanced by the interaction with F-127 micelles. The combined positive effect of EtOH and F-127 on the solubility was estimated. The aggregation number of F-127 micelles in the presence of 10% and 20% ethanol appeared to be reduced by 2.1-fold and 4.1-fold, respectively, as compared to buffer pH 7.4. The presence of ethanol in buffer pH 7.4 solution provided better solvent conditions but inhibited the formation of F-127 micelles. The impact of UMF on the aggregation number of F-127 was not pronounced and was expressed only by a slight increase of 1 and 3 units in 10% and 20% EtOH, respectively. According to the values of zeta potential, addition of EtOH reduced the stability of the system. The permeation of UMF in buffer pH 7.4 measured through the cellulose membrane MWCO 12–14 kDa was increased 1.4-fold by 10% EtOH. An increase in EtOH content to 20% reduced this effect to 1.2-fold. Decreasing effect of 1.5% F-127 on the permeability was inhibited by using 10% EtOH. The solution containing 1.5% F-127 and 10% EtOH was shown to be an advantageous system for UMF in view of the solubility–permeability balance. The authors suppose the findings of the study to be useful for the design of pharmaceutical formulations based on UMF antiviral drugs.

show abstract

“…form. The hydrophilic chain of HA-PHis was exposed owing to the long chain of PF127-FA, which caused the larger particle size [31].…”

Section: Morphological Observationmentioning

confidence: 99%

Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone

Yang

Zhang

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

Breast cancer has a high prevalence in the world and creates a substantial socio-economic impact. Polymer micelles used as nano-sized polymer therapeutics have shown great advantages in treating breast cancer. Here, we aim to develop a dual-targeted pH-sensitive hybrid polymer (HPPF) micelles for improving the stability, controlled-release ability and targeting ability of the breast cancer treatment options. The HPPF micelles were constructed using the hyaluronic acid modified polyhistidine (HA-PHis) and folic acid modified Plannick (PF127-FA), which were characterized via 1H NMR. The optimized mixing ratio (HA-PHis:PF127-FA) was 8:2 according to the change of particle size and zeta potential. The stability of HPPF micelles were enhanced with the higher zeta potential and lower critical micelle concentration compared with HA-PHis and PF127-FA. The drug release percents significantly increased from 45% to 90% with the decrease in pH, which illustrated that HPPF micelles were pH-sensitive owing to the protonation of PHis. The cytotoxicity, in vitro cellular uptake and in vivo fluorescence imaging experiments showed that HPPF micelles had the highest targeting ability utilizing FA and HA, compared with HA-PHis and PF127-FA. Thus, this study constructs an innovative nano-scaled drug delivery system, which provides a new strategy for the treatment of breast cancer.

show abstract

Direct and Reverse Pluronic Micelles: Design and Characterization of Promising Drug Delivery Nanosystems

Cited by 32 publications

References 121 publications

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

Fine-Tuning the Amphiphilic Properties of Carbosilane Dendritic Networks towards High-Swelling Thermogels

Revisiting the Solubility–Permeability Relationship with Hydrophobic Drug Umifenovir in Pluronic Solutions: Impact of pH and Co-Solvent

Design of Dual-Targeted pH-Sensitive Hybrid Polymer Micelles for Breast Cancer Treatment: Three Birds with One Stone

Contact Info

Product

Resources

About