Direct and Modular Access to Allylic Amines via Nickel-Catalyzed Three-Component Coupling
Changyu Xu,
Jianchao Chang,
Zhan Dong
et al.
Abstract:The preparation of allylic amines by transition metal catalysis has played an important role in synthetic chemistry; however, the main employment of prefunctionalized coupling partners through multistep synthesis from available starting materials limits the scope and applications of allylic amines. In this context, we develop a Ni-catalyzed three-component coupling of commercially available aldehydes, amines and alkenes. Avoiding the isolation of imine inter-mediate, this direct and modular approach delivers a… Show more
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