Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis

Liu, Fang; Pogoda, Hans-Martin; Pearson, Caroline Alayne; Ohyama, Katsumi; Löhr, Heiko; Hammerschmidt, Matthias; Placzek, Marysia

doi:10.1242/dev.080226

Cited by 39 publications

(47 citation statements)

References 56 publications

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“…In the case of the neurohypophysis, FGF3 and FGF10 have been demonstrated to promote vascularisation (Liu et al. ). Whether this role of FGFs is conserved in other CVOs remains to be determined.…”

Section: Later Specialisations Of Cvosmentioning

confidence: 99%

The origins of the circumventricular organs

Kiecker

2017

Journal of Anatomy

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The circumventricular organs (CVOs) are specialised neuroepithelial structures found in the midline of the brain, grouped around the third and fourth ventricles. They mediate the communication between the brain and the periphery by performing sensory and secretory roles, facilitated by increased vascularisation and the absence of a blood-brain barrier. Surprisingly little is known about the origins of the CVOs (both developmental and evolutionary), but their functional and organisational similarities raise the question of the extent of their relationship. Here, I review our current knowledge of the embryonic development of the seven major CVOs (area postrema, median eminence, neurohypophysis, organum vasculosum of the lamina terminalis, pineal organ, subcommissural organ, subfornical organ) in embryos of different vertebrate species. Although there are conspicuous similarities between subsets of CVOs, no unifying feature characteristic of their development has been identified. Cross-species comparisons suggest that CVOs also display a high degree of evolutionary flexibility. Thus, the term 'CVO' is merely a functional definition, and features shared by multiple CVOs may be the result of homoplasy rather than ontogenetic or phylogenetic relationships.

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Section: Later Specialisations Of Cvosmentioning

confidence: 99%

The origins of the circumventricular organs

Kiecker

2017

Journal of Anatomy

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Section: Anisotropic Growth Model Of Hypothalamic Developmentmentioning

confidence: 99%

“…Finally, having generated anterior and mammillary progenitors that extend in opposite directions, the Fgf10 +ive progenitor pool gives rise to another set(s) of progenitors: infundibular progenitors that grow ventrally. 41,42,54 Unlike anterior and mammillary progenitors, infundibular progenitors are glial in nature. Potentially, the Notch signalling pathway triggers a switch from neurogenesis to gliogenesis: in Hes1(−/−); Hes5(+/-) mutant embryos, progenitor cells differentiate into neurones at the expense of pituicytes (derivatives of the infundibulum: see below).…”

Section: Infundibular Progenitor Generation and Differentiationmentioning

confidence: 99%

Development of the basal hypothalamus through anisotropic growth

Pearson

Towers

et al. 2019

J Neuroendocrinology

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The adult hypothalamus is subdivided into distinct domains: pre‐optic, anterior, tuberal and mammillary. Each domain harbours an array of neurones that act together to regulate homeostasis. The embryonic origins and the development of hypothalamic neurones, however, remain enigmatic. Here, we summarise recent studies in model organisms that challenge current views of hypothalamic development, which traditionally have attempted to map adult domains to correspondingly located embryonic domains. Instead, new studies indicate that hypothalamic neurones arise from progenitor cells that undergo anisotropic growth, expanding to a greater extent than other progenitors, and grow in different dimensions. We describe in particular how a multipotent Shh / Fgf10 ‐expressing progenitor population gives rise to progenitors throughout the basal hypothalamus that grow anisotropically and sequentially: first, a subset displaced rostrally give rise to anterior‐ventral/tuberal neuronal progenitors; then a subset displaced caudally give rise to mammillary neuronal progenitors; and, finally, a subset(s) displaced ventrally give rise to tuberal infundibular glial progenitors. As this occurs, stable populations of Shh +ive and Fgf10 +ive progenitors form. We describe current understanding of the mechanisms that induce Shh +ive /Fgf10 +ive progenitors and begin to direct their differentiation to anterior‐ventral/tuberal neuronal progenitors, mammillary neuronal progenitors and tuberal infundibular progenitors. Taken together, these studies suggest a new model for hypothalamic development that we term the “anisotropic growth model”. We discuss the implications of the model for understanding the origins of adult hypothalamic neurones.

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“…Persistent SHH expression in the infundibular region results in loss of the pituitary organizer and reduction or loss of Rathke’s pouch (24,25). The pituitary organizer, especially FGF signaling, also acts as a chemoattractant for axons of oxytocin and vasopressin expressing neurons located in the paraventricular nucleus of the hypothalamus (26). The progenitor cells within the infundibular region give rise to the pituicytes, the glial-like cells of the posterior lobe, and Notch signaling through Hes1 and Hes5 is necessary for promoting pituicyte fate specification (27).…”

Section: Pituitary Organogenesis: Formation Of the Mature Gland From mentioning

confidence: 99%

Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways

Cheung

Davis

Brinkmeier

et al. 2017

Molecular and Cellular Endocrinology

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The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism.

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Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis

Cited by 39 publications

References 56 publications

The origins of the circumventricular organs

The origins of the circumventricular organs

Development of the basal hypothalamus through anisotropic growth

Regulation of pituitary stem cells by epithelial to mesenchymal transition events and signaling pathways

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