Direct analysis of solid samples by fs-LA-ICP-MS

Fernández, Beatriz; Claverie, Fanny; Pécheyran, Christophe; Donard, Olivier F. X.

doi:10.1016/j.trac.2007.08.008

Cited by 197 publications

(145 citation statements)

References 56 publications

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“…A critical comparison of analytical capabilities, with selected examples and trends of LA-ICP-MS, GD-MS and SIMS/SNMS, is presented here as they can be considered the most widespread and powerful inorganic MS techniques currently applied for the direct characterisation of solids at the nanoscale. For other ion sources enabling general solid-state inorganic analysis, the reader is invited to consult more general references [12][13][14][15].…”

Section: Solid State Mass Spectrometry Techniquesmentioning

confidence: 99%

“…Therefore, the influence of such parameters has been investigated in an attempt to minimise LA-ICP-MS limitations. Interesting developments have been mainly driven so far in two directions: the use of shorter wavelengths and of shorter laser pulses [15,26]. Both are aimed at a better localisation of the ablation event and, consequently, a more efficient and defined use of the delivered laser pulse energy.…”

Section: Laser Ablation Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

“…nanosecond) is the predominant thermal character of the process, which promotes modification and mixture of different layers of the sample. In contrast to nanosecond LA (ns-LA), fermtosecond LA (fs-LA) pulses generate a plasma with shorter lifetime, allowing more efficient energy transfer to the sample without the interaction of ejected material with the incoming laser pulse [15]. Margetic et al [28,29] showed the qualitative depth profiles obtained by fs-LA-TOFMS for semiconductor and metallic samples with coatings in the nanometre range: TiN-TiAlN multilayers of 280-nm thickness on an Fe substrate, and Cr-Ni multilayers of 55-nm thickness on a Si wafer.…”

Section: Laser Ablation Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

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Inorganic mass spectrometry as a tool for characterisation at the nanoscale

et al. 2009

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Inorganic mass spectrometry techniques may offer great potential for the characterisation at the nanoscale, because they provide unique elemental information of great value for a better understanding of processes occurring at nanometre-length dimensions. Two main groups of techniques are reviewed: those allowing direct solid analysis with spatial resolution capabilities, i.e. lateral (imaging) and/or indepth profile, and those for the analysis of liquids containing colloids. In this context, the present capabilities of widespread elemental mass spectrometry techniques such as laser ablation coupled with inductively coupled plasma mass spectrometry (ICP-MS), glow discharge mass spectrometry and secondary ion/neutral mass spectrometry are described and compared through selected examples from various scientific fields. On the other hand, approaches for the characterisation (i.e. size, composition, presence of impurities, etc.) of colloidal solutions containing nanoparticles by the well-established ICP-MS technique are described. In this latter case, the capabilities derived from the on-line coupling of separation techniques such as field-flow fractionation and liquid chromatography with ICP-MS are also assessed. Finally, appealing trends using ICP-MS for bioassays with biomolecules labelled with nanoparticles are delineated.

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Section: Solid State Mass Spectrometry Techniquesmentioning

confidence: 99%

Section: Laser Ablation Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

Section: Laser Ablation Inductively Coupled Plasma Mass Spectrometrymentioning

confidence: 99%

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Inorganic mass spectrometry as a tool for characterisation at the nanoscale

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“…LA-ICP-MS is established as a powerful and sensitive analytical technique in material and environmental research, in particular, for the investigation of highpurity materials, superhard materials of layered systems, or for monitoring of long-lived radionuclides in contaminated soil samples [18,19]. As a new application field LA-ICP-MS is employed in biological and medical research [20,21] for image (mapping) of the lateral element distribution in an entire sample [13,14,[22][23][24][25][26]. As an example, imaging LA-ICP-MS techniques were developed [27] for quantitative mapping of selected elements (P, S, Fe, Cu, Zn, and C) in thin sections of brain samples, infected and noninfected with tumor (thickness 20 m).…”

mentioning

confidence: 99%

“…However, in spite of all the advantages of the LA-ICP-MS technique, its application in some analytical tasks is limited by the restriction in focusing the laser beam due to the diffraction feature of the light and, therefore, a finite lateral resolution (from 5 to 300 m [1,28,29] that, in some cases, would be insufficient, for example, for the analysis of the fine structures of small regions of biological tissues and single cells [14,19,20] or in nanoelectronics [21]. For this reason, the known near-field effect can be applied to improve the spatial resolution of the laser that, recently, has proven the capability of the LA-ICP-MS technique for possible spatial analysis at nm resolution scale.…”

mentioning

confidence: 99%

Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Zoriy¹,

Mayer

Becker³

2009

J. Am. Soc. Mass Spectrom.

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An analytical mass spectrometric method for the elemental analysis of nano-bioelectronic devices involved in bioengineering research was developed and applied for measurements of selected metals (Au, Ti, Pt, Cr, etc.) on interdigitated electrode array chips (IDA-chip). An imaging laser ablation inductively coupled plasma mass spectrometric (LA-ICP-MS) procedure was used to map the elements of interest on the surface of the analyzed sample. The obtained images of metals were in a good agreement and corresponded to the micro-and nanofabricated metal electrode pattern. For the analysis at nanometer resolution scale a NF-LA-ICP-MS (NF-near-field) procedure was applied, which utilize thin Ag needle to enhance laser beam energy and improve spatial resolution of the method. The results show a ϳ100ϫ enhancement of analyte signal, when the needle was positioned in the "near-field region" to the sample surface and the laser shot was performed. In addition, mass spectrometric studies of reproducibly for five separated NF-LA shots in different places of analyzed sample yielded an RSD of the measurement of 16%. io engineering (or biological engineering), including biomedical engineering and nanobiotechnology, is a new, challenging, and rapidly growing high-tech research field [1,2]. The use of biomolecules as the building blocks of higher-level functional devices will lead to applications that range from the integration of biomaterials with electronics in recognition or sensing devices [3]. Bioelectronics research also exploits to use biomolecules to perform the electronic functions that semiconductor devices currently perform, thereby offering the potential to increase integration in combination with additional functionality at the nanometer level. However, the integration of biomolecules or even whole cells with inorganic devices brings several challenges about as there are, for instance, operation of the electronic components under physiological conditions, electrically, biochemically as well as size-adapted bioinorganic interfaces, and biocompatibility of the electronic devices. The implementation of these challenges and the realization of functional bioelectronic junctions require interdisciplinary research, including microengineering, biotechnology, surface chemistry, and analytical research.The fabrication of bioelectronic component on the basis of silicon microtechnology facilitates high integration densities, high spatial resolution, combining signal recording and transducing in one device at relatively low production costs. To build and assemble bioinorganic electronic components with well defined and optimized features, it usually requires control over impurities of trace levels contaminations, which can influence the physical, electrical, magnetic, and chemical properties of thin layered systems. In particular, the biocompatibility of device can be strongly affected by organic and inorganic impurities introduced during the fabrication processes. Therefore, powerful and sensitive trace analytical techniques are ne...

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Laser Ablation in Atomic Spectroscopy

Horn

2010

Encyclopedia of Analytical Chemistry

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This article covers the developments in the field of laser ablation and highlights the current issues under investigation. Fundamental parameters such pulse width, wavelength, elemental and isotopic fractionation, the ablation mechanism, precision, and accuracy as well the the available software packages for calculation and manipulation of the data obtained by laser ablation are discussed. Ongoing research is focused on elemental‐isotopic fractionation and on high‐precision stable isotope ratio determinations and the use of femtosecond pulses for ablation. The recent results obtained using femtosecond pulses for ablation illustrate that this analytical technique is still under development.

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Direct analysis of solid samples by fs-LA-ICP-MS

Cited by 197 publications

References 56 publications

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

Inorganic mass spectrometry as a tool for characterisation at the nanoscale

Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range

Laser Ablation in Atomic Spectroscopy

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