Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function
Anirban Bardhan,
Wes Brown,
Savannah Albright
et al.
Abstract:Conditionally controlled antisense oligonucleotides provide precise interrogation of gene function at different developmental stages in animal models. Few examples of small molecule‐induced activation of antisense function exist, and have been restricted to cyclic morpholinos, which can have significant background activity in the absence of the trigger. Here, we provide a new approach by introducing azido‐caged nucleobases that are site‐specifically introduced into antisense morpholinos. The caging group desig… Show more
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