Objectives
Numerous cases of long coronavirus disease 2019 (long COVID) have been reported in patients with autoimmune rheumatic diseases (ARD). Despite those reviews on clinical manifestations of long COVID in the general population, systematic reviews on ARD patients are scarce. Herein, we conducted a systematic review and meta-analysis on the prevalence and characteristics of long COVID in ARD patients.
Methods
We searched literature in PubMed and EMBASE as of December 27, 2022. Cohort, cross-sectional, and case-control studies relevant to long COVID in ARD patients were collected. Stratification based on the severity of COVID-19 infection and subtypes of rheumatic diseases (SARD [systemic autoimmune rheumatic disease] vs.s NARD [non–autoimmune rheumatic disease]) was also undertaken. A random-effects model was used in the meta-analysis.
Results
A total of 15 relevant studies were identified from the literature. The prevalence of long COVID was 56% (95%CI: 34%, 76%) in 2995 patients. Hospitalized COVID-19 patients had a higher proportion of long COVID than non-hospitalized patients. The prevalence of long COVID was similar between SARD and NARD patients. In terms of symptoms, fatigue, arthralgia, and pain were commonly complained in long COVID patients with ARD.
Conclusion
The characteristics of long COVID in ARD patients are generally similar to that in the general population despite a higher prevalence and a higher proportion of arthralgia and pain.