Dipsogenic potentiation by sodium chloride but not by sucrose or polyethylene glycol in tuberomammillary-mediated polydipsia

Mahía, Javier; Bernal, Antonio; Puerto, Amadeo

doi:10.1007/s00221-007-1018-9

Cited by 9 publications

(23 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The findings of the present study confirm previous reports on the high food consumption of ME‐lesioned animals between 30 and 48 hours post‐surgery . This may result from the impact of the lesion on mediobasal‐periventricular hypothalamic centres that participate in food intake, including the ME.…”

Section: Discussionsupporting

confidence: 91%

“…Lesions in the ME of rats produce a well‐documented neurological model of polydipsia and polyuria. ME lesions may interrupt some of the brain systems (eg, posterior hypothalamus‐hypophyseal axis) involved in hydromineral regulation, causing major derangements in the neuroendocrine control and regulation of water and sodium metabolism …”

Section: Discussionmentioning

confidence: 99%

“…After placing the animals in a stereotaxic device (Stoelting Co., Wood Dale, IL, USA), two burr holes were drilled into the skull at the rostral‐caudal and lateral coordinates of the ME. Next, a DCML‐5 lesion‐maker (Grass Instruments, Quincy, MA, USA) was used to administer bilateral anodic current (1.5 mA) application for 15 s, using a 00 stainless steel electrode insulated except at its tip. Stereotaxic coordinates, as obtained from the atlas of Paxinos and Watson, were 6.44 mm anterior to interaural line, 0.4 mm lateral to midline and 0.2 mm dorsal to interaural line.…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Effects of oxytocin administration on the hydromineral balance of median eminence‐lesioned rats

Mahía

Bernal

Puerto

2019

J Neuroendocrinology

View full text Add to dashboard Cite

In the clinical setting, acute injuries in hypothalamic mediobasal regions, along with polydipsia and polyuria, have been observed in patients with cerebral salt wasting (CSW). CSW is also characterised by hypovolaemia and hyponatraemia as a result of an early increase in natriuretic peptide activity. Salt and additional amounts of fluid are the main treatment for this disorder. Similarly, experimental lesions to these brain regions, which include the median eminence (ME), produce a well‐documented neurological model of polydipsia and polyuria in rats, which is preceded by an early sodium excretion of unknown cause. In the present study, oxytocin (OT) was used to increase the renal sodium loss and prolong the hydroelectrolyte abnormalities of ME‐lesioned animals during the first few hours post‐surgery. The objective was to determine whether OT‐treated ME‐lesioned animals increase their sodium appetite and water intake to restore the volume and composition of extracellular body fluid. Electrolytic lesion of the ME increased water intake, urinary volume and sodium excretion of food‐deprived rats and also decreased urine osmolality and estimated plasma sodium concentration. OT administration at 8 hours post‐surgery reduced water intake, urine output and plasma sodium concentration and also increased urine osmolality and urine sodium excretion between 8 and 24 hours post‐lesion. From 24 to 30 hours, more water and hypertonic NaCl was consumed by OT‐treated ME‐lesioned rats than by physiological saline‐treated‐ME‐lesioned animals. Food availability from 30 to 48 hours reduced the intake of hypertonic saline solution by ME/OT animals, which increased their water and food intake during this period. OT administration therefore appears to enhance the natriuretic effect of ME lesion, producing hydroelectrolyte changes that reduce the water intake of food‐deprived animals. Conversely, the presence of hypertonic NaCl increases the fluid intake of these animals, possibly as a result of the plasma sodium depletion and hypovolaemic states previously generated. Finally, the subsequent increase in food intake by ME/OT animals reduces their need for hypertonic NaCl but not water, possibly in response to osmotic thirst. These results are discussed in relation to a possible transient activation of the ME with the consequent secretion of natriuretic peptides stored in terminal swellings, which would be augmented by OT administration. Electrolytic lesion of the ME may therefore represent a useful neurobiological model of CSW.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Effects of oxytocin administration on the hydromineral balance of median eminence‐lesioned rats

Mahía

Bernal

Puerto

2019

J Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Arc is a critical center of feeding behavior in response to hunger sensation and has been suggested to be under the control of the histaminergic E3 neuronal cluster (Umehara et al, 2012). In summary, E3 may be involved in diurnal energy-osmoregulation because of the role of E3 in drinking behavior and urination (Mahia et al, 2007a(Mahia et al, , 2009 and the innervation of orexin (Torrealba et al, 2003).…”

Section: Discussionmentioning

confidence: 97%

Distribution of histaminergic neuronal cluster in the rat and mouse hypothalamus

Moriwaki

Chiba

Wei

et al. 2015

Journal of Chemical Neuroanatomy

View full text Add to dashboard Cite

Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histaminergic neurons arise in the posterior mesencephalon during the early embryonic period and gradually develop into two histaminergic substreams around the lateral area of the posterior hypothalamus and the more anterior peri-cerebral aqueduct area before finally forming an adult-like pattern comprising five neuronal clusters, E1, E2, E3, E4, and E5, at the postnatal stage. This distribution of histaminergic neuronal clusters in the rat hypothalamus appears to be a consequence of neuronal development and reflects the functional differentiation within each neuronal cluster. However, the close linkage between the locations of histaminergic neuronal clusters and their physiological functions has yet to be fully elucidated because of the sparse information regarding the location and orientation of each histaminergic neuronal clusters in the hypothalamus of rats and mice. To clarify the distribution of the five-histaminergic neuronal clusters more clearly, we performed an immunohistochemical study using the anti-HDC antibody on serial sections of the rat hypothalamus according to the brain maps of rat and mouse. Our results confirmed that the HDC-immunoreactive (HDCi) neuronal clusters in the hypothalamus of rats and mice are observed in the ventrolateral part of the most posterior hypothalamus (E1), ventrolateral part of the posterior hypothalamus (E2), ventromedial part from the medial to the posterior hypothalamus (E3), periventricular part from the anterior to the medial hypothalamus (E4), and diffusely extended part of the more dorsal and almost entire hypothalamus (E5). The stereological estimation of the total number of HDCi neurons of each clusters revealed the larger amount of the rat than the mouse. The characterization of histaminergic neuronal clusters in the hypothalamus of rats and mice may provide useful information for further investigations.

show abstract

“…group) (i.e. with an increase in water intake) (27–31). Hence, as suggested above, the NaCl content of the food available to these animals may be responsible for preventing the increase in water intake induced by OT administration, although other factors cannot be ruled out.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin Polyuria and Polydipsia is Blocked by NaCl Administration in Food‐Deprived Male Rats

Bernal

Mahía

Rio

et al. 2010

J Neuroendocrinology

Self Cite

View full text Add to dashboard Cite

We examined the effects of NaCl injections on the polydipsia and polyuria induced by subcutaneous oxytocin (OT) administration in food-deprived male rats. During the first 12 h of the treatment day, both food deprivation and OT administration increased urine excretion but reduced water intake, water balance (fluid intake minus urine volume) and body weight. OT treatment enhanced urine excretion and the reduction in water balance and body weight without reducing the water intake of food-deprived animals. Analysis of the physiological effects of OT administration showed increases in urinary sodium concentration, sodium excretion and a reduced plasma sodium concentration. During the second 12 h, OT increased both urine excretion and water intake in food-deprived but not in ad lib.-fed rats. However, hypertonic NaCl administration at the start of this second 12-h period blocked the polyuric and polydipsic responses observed in the OT/deprived group but increased the water intake of the ad lib. groups. After the whole 24-h period, animals treated with OT showed a water balance and body weight change matching those observed in Control animals. Although the recording time period is a critical factor to demonstrate the effect of peripheral OT administration on water intake, the results obtained suggest that the polyuric and polydipsic responses observed in food-deprived animals depend on the negative sodium and water balance induced by the natriuretic effect of OT and the unavailability of sodium. These OT-induced deficits can be counteracted by the administration of hypertonic NaCl solutions or simply by the intake of standard food.

show abstract

Dipsogenic potentiation by sodium chloride but not by sucrose or polyethylene glycol in tuberomammillary-mediated polydipsia

Cited by 9 publications

References 79 publications

Effects of oxytocin administration on the hydromineral balance of median eminence‐lesioned rats

Effects of oxytocin administration on the hydromineral balance of median eminence‐lesioned rats

Distribution of histaminergic neuronal cluster in the rat and mouse hypothalamus

Oxytocin Polyuria and Polydipsia is Blocked by NaCl Administration in Food‐Deprived Male Rats

Contact Info

Product

Resources

About