Diploid Hepatocytes Drive Physiological Liver Renewal in Adult Humans

Heinke, Paula; Rost, Fabian; Rode, Julian; Welsch, Thilo; Alkass, Kanar; Feddema, Joshua; Salehpour, Mehran; Possnert, Göran; Druid, Henrik; Brusch, Lutz; Bergmann, Olaf

doi:10.2139/ssrn.3677468

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Hepatocyte Polyploidy -Origin and Function1

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2021

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“…The exact timing of polyploidization in the human liver is less clear but, as in mice, it increases with age [16]. In line with reports analyzing mouse liver [22,28], homeostasis is mainly driven by diploid human hepatocytes [31].…”

Section: Hepatocyte Polyploidy -Origin and Functionmentioning

confidence: 93%

Polyploidy control in hepatic health and disease

Sladky

Eichin

Reiberger

et al. 2021

Journal of Hepatology

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Section: Hepatocyte Polyploidy -Origin and Functionmentioning

confidence: 93%