Diplofuranoxin, a disubstituted dihydrofuranone, was produced together with sphaeropsidin A and epi-sphaeropsidone by Diplodia subglobosa, an emerging ash (Fraxinus excelsior L.) pathogen in Europe

The incredible story of ophiobolin A and sphaeropsidin A: two fungal terpenes from wilt-inducing phytotoxins to promising anticancer compounds

“…In addition, sphaeropsidin A completely inhibited P. cambivora mycelium growth. 136 In addition to the above-described biological activities, sphaeropsidin A showed other activities with interesting potential in agriculture and medicine.…”

“…177 Finally, aspewentins N-R (158-162, Fig. 12) were isolated together with aspewentins A, D and K (145, 148 and 155) and sphaeropsidin C (136), respectively, from a rhizosphere soil-derived fungal strain, Aspergillus sp. WT03 collected under natural forest shade, Lichuan, Hubei Province, People's Republic of China.…”

“…The tricyclic pimarane system is an important feature to impart activity given that its disruption observed in derivative 180 strongly reduced the activity. The antimycotic activity of sphaeropsidins A-F (2,(135)(136)(137)(138)(139) and their derivatives (173)(174)(175)(176)(177)(178)(179)(180), respectively, was assayed against eight fungal species including S. cardinale, S. cupressi, and S. unicorne, which are causal agents of cypress canker disease, and ve other plant pathogenic fungi, namely, Botrytis cinerea, Fusarium oxysporum, Penicillium expansum, Phomopsis amygdali and Verticillium dahlia. Among the fungi tested, SphA showed the strongest antifungal activity against P. amygdali, while it was reduced against F. oxysporum and V. dahlia, which appeared to be less sensitive to the toxin.…”

Asymmetric total syntheses of aspilactonol F and aspiketolactonol and synthetic studies toward diplofuranoxin

“…The disubstituted dihydrofuranone diplofuranoxin 1h (Fig. 1) was isolated by Evidente and co-workers 9 from the pathogen Diplodia subglobosa in 2022. This pathogen is involved in aetiology of dieback in Europe, which is the main threat to the wood associated industry and European ash heritage.…”

Current status of Botryosphaeriaceae species in Italy: Impacts on agricultural crops and forest ecosystems

“…Grapevine foliar symptoms caused by fungal wood pathogens are usually associated with phytotoxic metabolites produced during wood colonization (Masi et al, 2018a(Masi et al, , 2018b. Some metabolites have activity against many fungal pathogens, such as com-pounds produced by D. corticola and D. subglobosa that could offer numerous benefits in multiple biotechnology sectors (Cimmino et al, 2016;Masi et al, 2022), and occurrence of typical chloro-necrotic foliar symptoms on grapevine have been associated with infections by Botryosphaeriaceae species (Dubos et al, 2001;Abou-Mansour et al, 2015).…”