Diphtheritic polyneuropathy in the wake of resurgence of diphtheria

Manikyamba, D.; Satyavani, A.; Ponnaiyan, Deepa

doi:10.4103/1817-1745.174441

Cited by 20 publications

(18 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Manikyamba et al reported isolated palatal palsy in 56% cases. 9 Mateen et al found palatal palsy only in 13% cases. 10 The onset of neurological complications in our series was seen from 6-51 days after respiratory symptoms.…”

Section: Discussionmentioning

confidence: 94%

A clinical study of complications of diphtheria

Arya

Maharia

Kadela

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

Background: Diphtheria is an acute infectious preventable disease of childhood caused by C. diphtheriae. Diphtheria is a localized infection of mucous membrane or skin.Methods: The present study was carried out in the Department of Otorhinolaryngology S.P. Medical College and associated group of hospital. In this study all cases of diphtheria and all age groups which attended ENT OPD and emergency department during period from 1/1/2010 to 31/12/2010 were included. Results: In the present study highest numbers of cases were recorded among 5-10 years of age followed by 0-5 year of age group. 57.59% patients were male and 42.41% patients were female. It was found that occurrence of diphtheria was highest in month November and October and was quit frequent during September and December. No cases during April, June and July. It was observed that most common post diphtheria complication was myocarditis (23.42%) followed by neurological complication.Conclusions: In order to prevent complication of the disease active immunization is customary and in order to detect the disease at early stage and for prompt treatment masses should be educated regarding the dreadful nature of the disease.

show abstract

Section: Discussionmentioning

confidence: 94%

A clinical study of complications of diphtheria

Arya

Maharia

Kadela

et al. 2019

Int J Otorhinolaryngol Head Neck Surg

View full text Add to dashboard Cite

show abstract

“…similar to reports from different centres (32-56.3%) in north India. 9,17 Late presentation when complications had already been set in, delayed ADS administration, financial constraints by care givers attributed to high case fatality rate in this series. This study made an important observation with regards to immunization status and disease related morbidity and fatality, as complete survival was observed in fully immunized group.…”

Section: Resultsmentioning

confidence: 94%

“…This finding was in accordance with the studies done by Arya et al, who observed palatal palsy(18.5%) as the commonest neurological complication and Manikyamba et al, also reported isolated palatal palsy in 56% cases. 16,17 None of the studies evaluated the outcome of palatal palsy in diphtheria cases. Respiratory failure due to diaphragmatic muscle weakness was seen in 5% of cases.…”

Section: Resultsmentioning

confidence: 99%

Resurgence of diphtheria and its outcome among children in western Uttar Pradesh: a battle to conquer

Bhatnagar

Sahai

2019

Int J Contemp Pediatr

View full text Add to dashboard Cite

Background: Considered as a rare clinical entity in immediate post-vaccination era, diphtheria has now started gaining surface in India for last few years, with an epidemiological shift involving older children owing to poor immunization coverage and waning immunity. Thus, it is imperative to quantify disease burden, analyses the clinical profile and factors affecting the outcome of diphtheria in children.Methods: A prospective observational study conducted in the Pediatric department of a teaching hospital where all children admitted with clinical diagnosis of diphtheria during the study period were included. Demographic data and clinically relevant information along with complications and outcome were recorded. Cases were managed as per standard treatment protocol providing intensive care support wherever required. Complications and factors affecting the outcome in all diphtheria cases were analysed.Results: Total 53 children were enrolled into study, and the mean age of study population was 7.55±2 years. Fever, pseudo membrane and throat pain were observed in all the cases. Palatal palsy was the earliest and the commonest complication (60.4%) followed by myocarditis (55%). Case fatality rate was 33.9% and myocarditis (77%) was the commonest complication attributing to it. Poor immunization status, late presentation and delayed ADS administration were associated with increased complication rate and unfavorable outcome.Conclusions: Robust immunization activity coupled with improved case-based surveillance would go a long way in preventing further diphtheria outbreaks in community. Sensitization about this re-emerging disease and high index of suspicion in diagnosing it, amongst primary care physicians and peripheral health workers would promote early referral and prompt management thereby reducing morbidity and high mortality associated with diphtheria.

show abstract

“…[ 14 ] Manikyamba et al . [ 4 ] also found oculomotor nerve involvement only in three cases (15%). Piradov et al .…”

Section: Discussionmentioning

confidence: 98%

“…Contrary to this, Manikyamba et al . [ 4 ] reported elevated protein levels in majority of the patients.…”

Section: Discussionmentioning

confidence: 99%

Prospective study of diphtheria for neurological complications

Prasad

Lata

2018

J Pediatr Neurosci

View full text Add to dashboard Cite

Aim:To study the spectrum of neurological complications of diphtheria, timing of onset with respect to respiratory disease, and pattern of recovery.Settings and Design:Prospective, observational, hospital-based study conducted in tertiary care hospital.Materials and Methods:Twenty-eight cases of diphtheria with neurological complications were admitted during the period of study. Demographic profile, age, gender, status of immunization, past history stressing on the severity of the respiratory disease, and complaints regarding diverse complications of diphtheria were recorded. Detailed clinical and central nervous system examinations along with relevant investigations were carried out.Results:Children were in the age group of 3–18 years. All 28 children presented with bulbar symptoms. Isolated palatal palsy was present in 18 children (64%). Third cranial involvement was present in four children. Three children had unilateral lower motor neuron facial palsy and one child had sixth cranial nerve palsy. Nine children developed symmetric limb weakness. Diaphragmatic palsy was present in three children with the onset from 1–3 weeks after pharyngeal diphtheria. Loss of vasomotor tone was present in two children. Recovery was complete in all 28 children.Conclusion:Pediatricians/neurophysicians should have a high index of suspicion to recognize diphtheritic polyneuropathy. It carries good prognosis, hence timely diagnosis and differentiation from other neuropathies is a prerequisite for rational management and contact tracing.

show abstract

Diphtheritic polyneuropathy in the wake of resurgence of diphtheria

Cited by 20 publications

References 11 publications

A clinical study of complications of diphtheria

A clinical study of complications of diphtheria

Resurgence of diphtheria and its outcome among children in western Uttar Pradesh: a battle to conquer

Prospective study of diphtheria for neurological complications

Contact Info

Product

Resources

About