Diphtheritic myocarditis: A case series and review of literature

Singh, Sumit; Gupta, Nitin; Saple, Pallavi

doi:10.4103/jfmpc.jfmpc_1396_20

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…The mechanism of arrhythmia in association with myocarditis is poorly understood. Dysrhythmias are commonly seen in Diphtheria‐associated myocarditis as a result of the Diphtheria Exotoxin's activity on the heart conduction system 23,29 . M. pneumoniae has been shown to produce an exotoxin as well 30,31 .…”

Section: Discussionmentioning

confidence: 99%

“…Dysrhythmias are commonly seen in Diphtheria‐associated myocarditis as a result of the Diphtheria Exotoxin's activity on the heart conduction system. 23 , 29 M. pneumoniae has been shown to produce an exotoxin as well. 30 , 31 This exotoxin is very similar in structure to the Pertussis exotoxin, which has been associated with a weakening of the negative chronotropic and inotropic action mediated by muscarinic receptors, 32 , 33 leading to tachyarrhythmias.…”

Section: Discussionmentioning

confidence: 99%

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Mycoplasma myocarditis presenting with sustained SVT and acute heart failure without signs of myocardiocytolysis and extra‐cardiac disease

Radaelli,

Keller,

Franca

et al. 2024

Clinical Case Reports

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Key Clinical MessageMycoplasma myocarditis is a rare but potentially serious condition that can cause inflammation of the heart muscle, leading to arrhythmia and heart failure. It is important to consider this condition in the differential diagnosis of young patients presenting with unexplained signs of heart failure and SVT, even in the absence of signs of myocardiocytolysis and extra‐cardiac disease.AbstractMycoplasma pneumoniae infections are often underdiagnosed as a great proportion of patients remain asymptomatic, pauci‐symptomatic, or exhibit varying presentations. M. Pneumoniae manifestations can affect different systems, including the heart, with the potential to lead to high degree of morbidity and debilitating sequelae. Here we present an atypical case of M. Pneumoniae associated myocarditis which presented with sustained refractory SVT, symptoms of heart failure, and with no signs of myocardiocytolysis, pulmonary involvement, or systemic infection. Given the lack of signs of myocardial inflammation, the patient was initially misdiagnosed with tachycardia induced cardiomyopathy (TIC), but later correctly diagnosed after showing signs of pneumonia during the hospitalization. The patient received the appropriate antibiotic treatment in addition to corticosteroids, was discharged on the 15th day of hospitalization, and completely recovered after 1 month with no arrhythmia recurrence and normalization of ventricular function.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mycoplasma myocarditis presenting with sustained SVT and acute heart failure without signs of myocardiocytolysis and extra‐cardiac disease

Radaelli,

Keller,

Franca

et al. 2024

Clinical Case Reports

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“…The most common cause of inflammatory cardiomyopathies in developed countries is lymphocytic myocarditis, frequently caused by a viral pathogenesis [ 25 ]. However, different causes have been reported such as coxsackieviruses and adenoviruses [ 26 , 27 ], coronavirus disease-19 related myocarditis [ 28 ], diphtheria [ 29 ], and typhoid fever [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national burdens of myocarditis, 1990–2019: systematic analysis from GBD 2019

et al. 2023

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Objectives Myocarditis, a health-threatening heart disease, is attracting increasing attention. This systematic study was conducted to study the prevalence of disease through the trends of incidence, mortality, disability-adjusted life years (DALYs) over the last 30 years, which would be helpful for the policymakers to better the choices for reasonable decisions. Methods The global, regional, and national burdens of myocarditis from 1990–2019 were analyzed by using the 2019 Global Burden of Disease (GBD) database. This study on myocarditis produced new findings according to age, sex, and Social-Demographic Index (SDI) by investigating DALYs, age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and corresponding estimated annual percentage change (EAPC). Results The number of myocarditis incidence increased by 62.19%, from 780,410 cases in 1990 to 1,265,770 cases in 2019. The ASIR decreased by 4.42% (95%CI, from -0.26% to -0.21%) over the past 30 years. The number of deaths from myocarditis increased by 65.40% from 19,618 in 1990 to 324,490 in 2019, but the ASDR was relatively stable over the investigated period. ASDR increased in low-middle SDI regions (EAPC=0.48; 95%CI, 0.24 to 0.72) and decreased in low SDI regions (EAPC=-0.97; 95%CI, from -1.05 to -0.89). The age-standardized DALY rate decreased by 1.19% (95%CI, from -1.33% to -1.04%) per year. Conclusions Globally, the ASIR and DALY for myocarditis decreased and the ASDR was stable over the past 30 years. The risk of incidences and death cases increased with age. Measures should be taken to control the risk of myocarditis in high-burden regions. Medical supplies should be improved in the high-middle SDI regions and middle SDI regions to reduce the deaths from myocarditis in these regions.

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Bacterial toxins and heart function: heat-labile Escherichia coli enterotoxin B promotes changes in cardiac function with possible relevance for sudden cardiac death

Ferreira,

Cardozo,

Sastre

et al. 2023

Biophys Rev

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Diphtheritic myocarditis: A case series and review of literature

Cited by 3 publications

References 9 publications

Mycoplasma myocarditis presenting with sustained SVT and acute heart failure without signs of myocardiocytolysis and extra‐cardiac disease

Mycoplasma myocarditis presenting with sustained SVT and acute heart failure without signs of myocardiocytolysis and extra‐cardiac disease

Global, regional, and national burdens of myocarditis, 1990–2019: systematic analysis from GBD 2019

Bacterial toxins and heart function: heat-labile Escherichia coli enterotoxin B promotes changes in cardiac function with possible relevance for sudden cardiac death

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